Antimicrobial Phenolics and Unusual Glycerides from Helichrysum italicum subsp. microphyllum
| Autor: | Federica Pollastro, Mauro Ballero, Simon Gibbons, Giuseppina Chianese, Blessing Mabebie, Alberto Minassi, Warunya Arunotayanun, Orazio Taglialatela-Scafati, Giovanni Appendino |
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| Přispěvatelé: | TAGLIALATELA SCAFATI, Orazio, F., Pollastro, Chianese, Giuseppina, A., Minassi, S., Gibbon, W., Arunotayanun, B., Mabebie, M., Ballero, G., Appendino |
| Rok vydání: | 2012 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Glyceride Pharmaceutical Science Microbial Sensitivity Tests Phloroglucinol Biology medicine.disease_cause Helichrysum italicum Glycerides Analytical Chemistry chemistry.chemical_compound Phenols Drug Discovery Botany medicine Helichrysum Pharmacology Molecular Structure Mediterranean Region Organic Chemistry Antimicrobial biology.organism_classification Pyrone Anti-Bacterial Agents Complementary and alternative medicine chemistry Pyrones Staphylococcus aureus Molecular Medicine Mediterranean area Antibacterial activity |
| Zdroj: | Journal of Natural Products. 76:346-353 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np3007149 |
| Popis: | During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a-c, 6-8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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