Catecholamines are mitogenic in 3T3 and bovine aortic endothelial cells
| Autor: | Renato N. Mascardo, Peter Sherline |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1984 |
| Předmět: |
DNA Replication
medicine.medical_specialty Endothelium Epinephrine medicine.medical_treatment Biology Mice Phentolamine Internal medicine medicine Prazosin Animals Receptor Aorta Cells Cultured DNA synthesis Epidermal Growth Factor Growth factor Cell Cycle Yohimbine General Medicine Endothelial stem cell Kinetics medicine.anatomical_structure Endocrinology Cattle Mitogens medicine.drug Research Article |
| Popis: | We have found that catecholamines stimulate DNA synthesis and centrosomal separation in 3T3 and bovine aortic endothelial cells cultured in the absence of serum or added growth factors. The mitogenic effect is mediated by an alpha 1-adrenergic receptor, as it is inhibited by phentolamine and prazosin but not by propranolol or yohimbine. The physiological and pathological consequences of this effect remain to be determined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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