P-Glycoprotein Expression in Acute Myeloid Leukaemia Cells at Diagnosis: Its relationship to Daunorubicin or Idarubicin Induction Therapy and Survival
| Autor: | Daniela Belotti, M. Carpenedo, Gianmarco Corneo, I.R. Miccolis, Enrico Pogliani |
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| Přispěvatelé: | Pogliani, E, Carpenedo, M, Miccolis, I, Belotti, D, Corneo, G |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Anthracycline Daunorubicin P-glycoprotein Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Idarubicin Survival rate Acute myeloid leukemia biology business.industry Hematology Multiple drug resistance Regimen 030220 oncology & carcinogenesis biology.protein Myeloid leukaemia business 030215 immunology medicine.drug |
| Zdroj: | Hematology (Amsterdam, Netherlands). 5(5) |
| ISSN: | 1024-5332 |
| Popis: | We investigated the expression of P-glycoprotein (P-gp) in 50 adults with de novo diagnosed acute myeloid leukaemia (AML) and the relationship between presence of P-gp in leukaemic cells and efficacy, as remission induction and survival rate, of two different anthracyclines, daunorubicin (DNR) and idarubicin (IDR). We found that 30 out of 50 patients (60%) were negative (Group 1) and 20 (40%) were positive (Group 2) for P-gp expression evaluated by mean of MRK16 MoAb using a cut-off of 10% positive cells. Thirty-five out of 50 patients (70%) obtained complete remission (CR); depending on P-gp expression, the CR rate was 80% for group 1 and 45% for group 2 (p < 0.005). The median duration of overall survival was 20 months for patients in Group 1 as compared with 10 months for patients of Group 2 (p < 0.005). Regarding the anthracycline used, no significant difference in CR was observed in patients of Group 1 (75% of CR with DNR vs. 90% with IDR); Group 2 obtained 40% of CR with DNR vs. 70% with IDR (p < 0.005). The median duration of overall survival (OS) with the two regimens was comparable in Group 1, while it was significantly longer in patients of Group 2 treated with IDR compared with DNR regimen (p < 0.005). These results confirm the prognostic value of P-gp expression in AML at first appearance and we suggest that idarubicin could be a valid anthracycline drug in the treatment of AML to be evaluated as potential drug of choice in patients with primary or drug-induced multidrug resistance. |
| Databáze: | OpenAIRE |
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