Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron
| Autor: | Kaylynn E. Coates, J. Scott Lauritzen, Davi D. Bock, Feng Li, Xiaonan Zhang, Quentin Gaudry, Andrew M. Dacks, Cengiz Günay, Steven A. Calle-Schuler |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Arthropod Antennae
QH301-705.5 Science Green Fluorescent Proteins Olfaction Stimulus (physiology) Biology Serotonergic General Biochemistry Genetics and Molecular Biology Olfactory Receptor Neurons dendrite 03 medical and health sciences 0302 clinical medicine Stimulus modality Neuropil medicine Animals Biology (General) 030304 developmental biology 0303 health sciences General Immunology and Microbiology D. melanogaster General Neuroscience Brain General Medicine serotonin Electrophysiology medicine.anatomical_structure Drosophila melanogaster nervous system Odorants Synapses neuromodulation Medicine Antennal lobe Female Drosophila Neuron Research Advance Neuroscience compartmental model 030217 neurology & neurosurgery Serotonergic Neurons olfaction |
| Zdroj: | eLife, Vol 8 (2019) eLife |
| Popis: | Serotonin plays different roles across networks within the same sensory modality. Previously, we used whole-cell electrophysiology in Drosophila to show that serotonergic neurons innervating the first olfactory relay are inhibited by odorants (Zhang and Gaudry, 2016). Here we show that network-spanning serotonergic neurons segregate information about stimulus features, odor intensity and identity, by using opposing coding schemes in different olfactory neuropil. A pair of serotonergic neurons (the CSDns) innervate the antennal lobe and lateral horn, which are first and second order neuropils. CSDn processes in the antennal lobe are inhibited by odors in an identity independent manner. In the lateral horn, CSDn processes are excited in an odor identity dependent manner. Using functional imaging, modeling, and EM reconstruction, we demonstrate that antennal lobe derived inhibition arises from local GABAergic inputs and acts as a means of gain control on branch-specific inputs that the CSDns receive within the lateral horn. |
| Databáze: | OpenAIRE |
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