Cerebellar volume in early-onset schizophrenia and its association with severity of symptoms
| Autor: | Selim Karabekir, Serkan Turan, Burcu Serim Demirgören, Goksin Nilufer Yonguc, Nuket Mas, Aylin Özbek, Özlem Gencer Kidak, Bari Ay, Ayşe Semra Hız, Ayşe İpek Polat |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Cerebellum Pathology medicine.medical_specialty Medicine (General) cerebellum Adolescent Clinical Research Reports Pharmacology toxicology Stereology 030204 cardiovascular system & hematology Biochemistry Severity of Illness Index 03 medical and health sciences 0302 clinical medicine R5-920 medicine Humans Age of Onset Association (psychology) Cerebrum Retrospective Studies Psychiatric Status Rating Scales medicine.diagnostic_test Early onset schizophrenia business.industry Biochemistry (medical) Positive and Negative Syndrome Scale (PANSS) Magnetic resonance imaging Early-onset schizophrenia general functionality Cell Biology General Medicine Organ Size medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure nervous system Schizophrenia 030220 oncology & carcinogenesis stereology Female business |
| Zdroj: | The Journal of International Medical Research Journal of International Medical Research, Vol 47 (2019) |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | ObjectivesThis study aimed to investigate whether early-onset schizophrenia (EOS) cases differ from controls regarding volumes of the total cerebellum and the right and left cerebellar hemispheres, and volumetric asymmetry. Correlations of cerebellar volumes and asymmetry indices with severity of symptoms and general functioning in cases of EOS were also assessed.MethodsAdolescents with EOS (n = 23) were compared with controls (n = 23). Sociodemographic and clinical data, and magnetic resonance imaging scans that were acquired for routine clinical purposes were collected retrospectively. Cerebellar volumes were evaluated using the stereological method. Asymmetry indices were subsequently calculated. Scores of the Positive and Negative Syndrome Scale and the Children’s Global Assessment Scale were used to assess the severity of symptoms and general functionality.ResultsThere were no significant differences in any of the cerebellar volumes and asymmetry indices between the two groups. Neither cerebellar volumes nor asymmetry indices were correlated with the severity of symptoms and general functionality in EOS.ConclusionsOur findings suggest that the early-onset form of schizophrenia does not show apparent volumetric changes of the cerebellum. Additionally, the neural circuits involved in formation of symptomatology may not reflect any correlation with cerebellar volumes at mid-adolescence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|