Neurofibrillary lesions in experimental aluminum-induced encephalopathy and Alzheimer's disease share immunoreactivity for amyloid precursor protein, Aβ, α1-antichymotrypsin and ubiquitin-protein conjugates
| Autor: | Jia Liu, Michael R. Wills, Christos D. Katsetos, Mary M. Herman, Yue Huang, John Savory |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Pathology medicine.medical_specialty alpha 1-Antichymotrypsin Immunoblotting Tau protein Encephalopathy Alpha (ethology) Amyloid beta-Protein Precursor Ubiquitin Alzheimer Disease medicine Amyloid precursor protein Animals Humans Ubiquitins Molecular Biology Brain Diseases Amyloid beta-Peptides biology Chemistry General Neuroscience Neurofibrillary Tangles medicine.disease Immunohistochemistry Molecular biology Biochemistry of Alzheimer's disease biology.protein Rabbits Neurology (clinical) Aluminum Developmental Biology Conjugate |
| Zdroj: | Brain Research. 771:213-220 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(97)00780-4 |
| Popis: | Neurofibrillary tangles of Alzheimer's disease contain predominantly tau protein and to a lesser degree amyloid precursor protein (APP), A beta protein, alpha 1-antichymotrypsin (ACT) and ubiquitin. Previously we have demonstrated the presence of phosphorylated tau and neurofilament proteins in neurofibrillary degeneration (NFD) induced by aluminum (Al) maltolate in rabbits [Savory et al., Brain Res. 669 (1995) 325-329; Savory et al., Brain Res. 707 (1996) 272-281]. Using the same animal system we have now detected APP, A beta, ACT and ubiquitin-like immunoreactivities in NFD-bearing neurons, often colocalizing in the NFD. Diffuse cytoplasmic staining for APP, A beta and ubiquitin was also present in neurons without NFD from Al maltolate-treated rabbits. This study provides additional support for immunochemical similarities between Al-induced NFD in rabbits and the neurofibrillary tangles in human subjects with Alzheimer's disease. |
| Databáze: | OpenAIRE |
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