Clinical and dermoscopic evaluation of combined (salicylic acid 20% and azelaic acid 20%) versus trichloroacetic acid 25% chemical peel in acne: an RCT

Autor:	Rehab A. Hegazy, Rania M. Abdel Hay, Mohamed Farouk Abdel Hady, Noha A. Saleh
Rok vydání:	2019
Předmět:	Adult Male medicine.medical_specialty Azelaic acid Adolescent Erythema Chemical peel Dermoscopy Dermatology Severity of Illness Index law.invention Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chemexfoliation Randomized controlled trial law Acne Vulgaris medicine Humans Dicarboxylic Acids Trichloroacetic Acid Trichloroacetic acid Acne 030203 arthritis & rheumatology business.industry Significant difference medicine.disease Treatment Outcome chemistry Patient Satisfaction Female medicine.symptom Salicylic Acid business Salicylic acid medicine.drug
Zdroj:	Journal of Dermatological Treatment. 30:572-577
ISSN:	1471-1753 0954-6634
DOI:	10.1080/09546634.2018.1484876
Popis:	Background: Combined azelaic acid (AA) and salicylic acid (SA) have not been previously used for acne. Objective: To compare the efficacy of this combination versus trichloroacetic acid (TCA) 25% peel in acne. Methods: Thirty-four patients were included in this trial. Patients received four sessions 2 weeks apart. The combined solution was applied to one side of the face, while TCA was applied to the other. Our outcomes were physician-reported clinical improvement, dermoscopic assessment of the erythema and patient's satisfaction. Results: After two sessions, a significant clinical improvement was observed in non-inflammatory lesions in the TCA-treated side-treated TCA and in inflammatory lesions in the SA/AA-treated side. At the end, both modalities led to significant improvement, with no significant difference in between. Patients reported more discomfort with the TCA-treated side. There was no significant different clinical improvement in both treated sides as regards SPT. Erythema improved in both sides. Patients were more satisfied by the SA/AA-treated side. Conclusion: Chemical peeling is effective in controlling mild-moderate acne in SPT III-IV. Combined SA 20% and AA 20% are recommended at early stage of treatment if patients have more inflammatory lesions, while TCA is recommended if patients have more non-inflammatory lesions.
Databáze:	OpenAIRE
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