Microglia in Alzheimer's disease: Local heroes!
| Autor: | Nàdia Villacampa, Michael T. Heneka |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Amyloid Immunology Plaque Amyloid Disease 03 medical and health sciences 0302 clinical medicine Neuroinflammation Alzheimer Disease hemic and lymphatic diseases Immunology and Allergy Medicine Humans Myeloid Cells ddc:610 Microglia business.industry Brief Definitive Report Plaque Atherosclerotic 030104 developmental biology medicine.anatomical_structure nervous system Myeloid cells business 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | The Journal of Experimental Medicine Journal of experimental medicine 217(4), e20192311 (2020). doi:10.1084/jem.20192311 |
| ISSN: | 1540-9538 |
| Popis: | Fate mapping of resident microglia and peripheral monocytes reveals that the myeloid cells that migrate to and associate with amyloid plaques in a mouse model of Alzheimer’s disease are exclusively derived from resident microglia. Alzheimer’s disease (AD) is accompanied by a robust inflammatory response mediated by plaque-associated myeloid cells of the brain. These cells exhibit altered gene expression profiles and serve as a barrier, preventing neuritic dystrophy. The origin of these cells has been controversial and is of therapeutic importance. Here, we genetically labeled different myeloid populations and unequivocally demonstrated that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia, with no contribution from circulating peripheral monocytes. |
| Databáze: | OpenAIRE |
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