Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon
| Autor: | Vanessa dos Santos Morais, Ester Cerdeira Sabino, Eric Delwart, Edcelha Soares D’Athaide Ribeiro, Danielle Elise Gill, Élcio Leal, Xutao Deng, Roberta Marcatti, Fred Julio Costa Monteiro, Fabiola Villanova, Geovani de Oliveira Ribeiro, Emerson Luiz Lima Araújo, Marlisson Octavio da S Rego, Steven S. Witkin, Antonio Charlys da Costa |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Serotype Genotype viruses 030231 tropical medicine Dengue virus phylogeography Serogroup medicine.disease_cause Arbovirus Microbiology Article Disease Outbreaks Dengue fever Evolution Molecular Dengue 03 medical and health sciences 0302 clinical medicine flavivirus Virology evolution medicine Humans Amazon Molecular epidemiology biology Genetic Variation virus diseases Dengue Virus biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification QR1-502 genomic surveillance Flavivirus 030104 developmental biology Infectious Diseases Viral phylodynamics arbovirus RNA Viral Brazil |
| Zdroj: | Viruses, Vol 13, Iss 689, p 689 (2021) Viruses Volume 13 Issue 4 |
| ISSN: | 1999-4915 |
| Popis: | Dengue virus (DENV) is a mosquito-borne viral pathogen that plagues many tropical-climate nations around the world, including Brazil. Molecular epidemiology is a growing and increasingly invaluable tool for understanding the dispersal, persistence, and diversity of this impactful virus. In this study, plasma samples (n = 824) from individuals with symptoms consistent with an arboviral febrile illness were analyzed to identity the molecular epidemiological dynamics of DENV circulating in the Brazilian state of Amapá. Twelve DENV type 1 (DENV-1) genomes were identified, which were phylogenetically related to the BR4 lineage of genotype V. Phylodynamics analysis suggested that DENV-1 BR-4 was introduced into Amapá around early 2010, possibly from other states in northern Brazil. We also found unique amino acids substitutions in the DENV-1 envelope and NS5 protein sequences in the Amapá isolates. Characterization of the DENV-1 BR-4 sequences highlights the potential of this new lineage to drive outbreaks of dengue in the Amazon region. |
| Databáze: | OpenAIRE |
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