A case of EBV-associated lymphoproliferative disease following high-dose therapy and CD34-purified autologous peripheral blood progenitor cell transplantation
| Autor: | AJ Peniket, Catherine D. Williams, Ah Goldstone, David C. Linch, A Macmillan, Michael J. Watts, AR Perry, PG Isaacson |
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| Rok vydání: | 1998 |
| Předmět: |
Epstein-Barr Virus Infections
Transplantation Conditioning medicine.medical_treatment T-Lymphocytes Lymphoproliferative disorders Antigens CD34 Hematopoietic stem cell transplantation Opportunistic Infections Lymphocyte Depletion Fatal Outcome hemic and lymphatic diseases medicine Humans Multiple myeloma Transplantation business.industry Bone Marrow Purging Hematopoietic Stem Cell Transplantation Hematology Middle Aged medicine.disease Bone marrow purging Lymphoproliferative Disorders Lymphoma Lymphocyte Transfusion Immunology Female Stem cell business Multiple Myeloma |
| Zdroj: | Bone marrow transplantation. 22(3) |
| ISSN: | 0268-3369 |
| Popis: | A fatal case of EBV-associated lymphoproliferative disorder arising after a CD34-selected autologous peripheral blood stem cell transplant is reported in a patient with multiple myeloma in first plateau phase. It is suggested that this is likely to be a consequence of the accessory cell depletion associated with the CD34+ cell purification and it is recommended that a source of autologous T cells is stored before transplantation to be used if a severe opportunistic infection or EBV lymphoma arises post-transplantation. |
| Databáze: | OpenAIRE |
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