Consequences of pilocarpine-induced status epilepticus in immunodeficient mice
| Autor: | Iara Ribeiro Silva, Daniele Suzete Persike, Maria da Graça Naffah Mazzacoratti, Astrid Nehlig, Thiago Vignoli, Rita de Cassia Sinigaglia Galli Coimbra, Silvia Maria Gomes Massironi, Maria José da Silva Fernandes, Eduardo Ferreira de Castro Neto |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Pathology Hippocampus Glutamic Acid Mice Nude Cell Count Status epilepticus Biology Mice Status Epilepticus Seizures Cortex (anatomy) Piriform cortex Internal medicine medicine Animals Molecular Biology Neurons Cell Death General Neuroscience Dentate gyrus Glutamate receptor Pilocarpine Brain Entorhinal cortex medicine.anatomical_structure Endocrinology nervous system Neurology (clinical) medicine.symptom Proto-Oncogene Proteins c-fos Developmental Biology medicine.drug |
| Zdroj: | Brain research. 1450 |
| ISSN: | 1872-6240 |
| Popis: | Systemic injection of pilocarpine in rodents induces status epilepticus (SE) and reproduces the main characteristics of temporal lobe epilepsy (TLE). Different mechanisms are activated by SE contributing to cell death and immune system activation. We used BALB/c nude mice, a mutant that is severely immunocompromised, to characterize seizure pattern, neurochemical changes, cell death and c-Fos activation secondarily to pilocarpine-induced SE. The behavioral seizures were less severe in BALB/c nude than in BALB/c wild type mice. However, nude mice presented more tonic-clonic episodes and higher mortality rate during SE. The c-Fos expression was most prominent in the caudate-putamen, CA3 (p |
| Databáze: | OpenAIRE |
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