Medial temporal structures and memory functions in adolescents with heavy cannabis use
| Autor: | Philip A. Cook, David Roofeh, Manzar Ashtari, James C. Gee, Laura Cyckowski, Serge Sevy, Kelly L. Cervellione, Brian B. Avants, Sanjiv Kumra |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Marijuana Abuse medicine.medical_specialty Adolescent media_common.quotation_subject Neuropsychological Tests Verbal learning Article Temporal lobe Young Adult Imaging Three-Dimensional medicine Humans Child Cannabis Dependence Psychiatry Biological Psychiatry media_common Analysis of Variance Brain Mapping Memory Disorders California Verbal Learning Test biology Verbal Learning Abstinence medicine.disease biology.organism_classification Magnetic Resonance Imaging Temporal Lobe Psychiatry and Mental health Schizophrenia Linear Models Female Cannabis Psychology Clinical psychology Psychopathology |
| Zdroj: | Journal of Psychiatric Research. 45:1055-1066 |
| ISSN: | 0022-3956 |
| Popis: | Converging lines of evidence suggest an adverse effect of heavy cannabis use on adolescent brain development, particularly on the hippocampus. In this preliminary study, we compared hippocampal morphology in 14 "treatment-seeking" adolescents (aged 18-20) with a history of prior heavy cannabis use (5.8 joints/day) after an average of 6.7 months of drug abstinence, and 14 demographically matched normal controls. Participants underwent a high-resolution 3D MRI as well as cognitive testing including the California Verbal Learning Test (CVLT). Heavy-cannabis users showed significantly smaller volumes of the right (p |
| Databáze: | OpenAIRE |
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