Differentiation between radiation-induced brain injury and glioma recurrence using 3D pCASL and dynamic susceptibility contrast-enhanced perfusion-weighted imaging
| Autor: | Yan Wang, Xin Lou, Hua-Feng Xiao, Lin Ma, Ying Li, Yu-Lin Wang, Gang Liu, Si Chen |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Adolescent Radiation induced 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences Young Adult 0302 clinical medicine Text mining Imaging Three-Dimensional Glioma medicine Humans Radiology Nuclear Medicine and imaging Radiation Injuries Aged business.industry Brain Neoplasms Hematology Middle Aged medicine.disease Magnetic Resonance Imaging Oncology Perfusion weighted Brain Injuries Cerebrovascular Circulation Arterial spin labeling Female Spin Labels medicine.symptom Neoplasm Recurrence Local business Nuclear medicine Perfusion 030217 neurology & neurosurgery Dynamic susceptibility |
| Zdroj: | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 129(1) |
| ISSN: | 1879-0887 |
| Popis: | This study was performed to validate the efficacy of three-dimensional pseudocontinuous arterial spin labeling (pCASL) compared with dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI) in distinguishing radiation-induced brain injury from glioma recurrence in patients with glioma.Both 3D pCASL and DSC-PWI were performed using a 3.0 Tesla scanner in 69 patients with previously resected and irradiated glioma who displayed newly developed abnormal contrast-enhanced lesions. The included patients were classified into a radiation-induced brain injury group (n = 34) and a glioma recurrence group (n = 35) based on subsequent pathologic analysis or clinical-radiological follow-up. Lesion perfusion parameter values (CBF and nCBF on pCASL, nrCBV and nrCBF on DSC-PWI) were measured and compared between the two groups using Student's t test. Pearson correlation analysis was performed to evaluate the correlation between pCASL (CBF and nCBF) and DSC-PWI (nrCBV and nrCBF) values in the contrast-enhanced lesions and in the perifocal edema regions.For the contrast-enhanced lesions, the CBF, nCBF, nrCBV, and nrCBF (29.46 ± 15.08 ml/100 g/min, 1.11 ± 0.50, 1.39 ± 1.15, and 1.30 ± 0.74) in the radiation-induced brain injury group were significantly lower than those (64.52 ± 33.92 ml/100 g/min, 2.73 ± 1.71, 3.39 ± 2.12, and 3.20 ± 1.95) in the glioma recurrence group (P 0.001). The CBF and nCBF demonstrated strong correlation with nrCBV and nrCBF in the contrast-enhanced lesions.Radiation-induced brain injury and glioma recurrence can be reliably distinguished using both 3D pCASL and DSC-PWI. Contrast-free 3D pCASL is a suitable alternative to DSC-PWI for long-term follow-up in glioma patients with postoperative radiotherapy. |
| Databáze: | OpenAIRE |
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