Meningococcal disease in childhood—a regional study in Ireland
| Autor: | M. Byrne, A. C. Moloney, J. Fogarty, C. T. Keane, R. Carroll |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Microbiology (medical) Pediatrics medicine.medical_specialty Adolescent Meningococcal Vaccines Disease Meningococcal disease Group B Epidemiology medicine Humans Child Retrospective Studies business.industry Incidence Incidence (epidemiology) Vaccination Age Factors Infant Retrospective cohort study medicine.disease Meningococcal Infections Infectious Diseases El Niño Child Preschool Bacterial Vaccines Female Seasons business Ireland Meningitis |
| Zdroj: | Journal of Infection. 28:199-207 |
| ISSN: | 0163-4453 |
| Popis: | Summary A retrospective study of microbiology laboratory records of culture-confirmed cases of meningococcal disease in children under 14 years of age, admitted to four Dublin hospitals, was conducted for the period 1981–1991 inclusive. The study aimed to describe the epidemiology of meningococcal disease in childhood and to assess the potential of meningococcal group A and C vaccine in preventing disease. There were 406 cases of meningococcal disease of which 319 (78·6 %) were in children under 5 years of age. The meningitis to septicaemia ratio was almost 4:1 (320 vs. 86 cases). Of the 406 cases, 216 (53·2 %) cases occurred during the period November to March. The age-specific annual incidence rates for the Eastern Health Board region served was 64·2 per 100 000 under 1 year of age and 24·6 per 100 000 under 5 years of age. A relative increase in disease caused by meningococcal serogroup C was observed during the period of the study. Only 15 % all cases could have been prevented by a policy of universal meningococcal group A and C immunisation at 2 years of age. Such a policy, therefore, is not recommended. A vaccine for preventing disease caused by meningococcal group B is urgently required. |
| Databáze: | OpenAIRE |
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