Persistence and clearance of high‐risk human papillomavirus and cervical dysplasia at 1 year in women living with human immunodeficiency virus: a prospective cohort study
| Autor: | Adrienne L. Erlinger, Michele R. Hacker, Boikhutso Simon, Doreen Ramogola-Masire, Sikhulile Moyo, Rebecca Luckett, Cortney Eakin, Lynnette Tumwine Kyokunda, Katharine M. Esselen, Alexander Seiphetlheng, Helena Painter, Chelsea Morroni, Sarah Feldman |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Population Human immunodeficiency virus (HIV) Uterine Cervical Neoplasms HIV Infections Cervix Uteri Alphapapillomavirus medicine.disease_cause Article Persistence (computer science) 03 medical and health sciences 0302 clinical medicine Internal medicine Prevalence medicine Humans Prospective Studies Prospective cohort study education Early Detection of Cancer education.field_of_study Botswana 030219 obstetrics & reproductive medicine business.industry Incidence Incidence (epidemiology) Papillomavirus Infections HPV infection HIV virus diseases Obstetrics and Gynecology Middle Aged Uterine Cervical Dysplasia medicine.disease female genital diseases and pregnancy complications Dysplasia Female Histopathology Triage business Follow-Up Studies |
| Zdroj: | BJOG |
| ISSN: | 1471-0528 1470-0328 |
| Popis: | OBJECTIVE Evaluate 1-year outcomes of cervical cancer screening and treatment using primary high-risk human papillomavirus (HPV) testing in women living with human immunodeficiency virus (HIV). DESIGN Prospective cohort study. SETTING HIV treatment centre in Botswana. POPULATION Women living with HIV. METHODS Participants underwent cervical cancer screening with high-risk HPV testing and triage evaluation at baseline and 1-year follow up. Excisional treatment was offered as indicated. Histopathology was the reference standard. MAIN OUTCOME MEASURES Persistence, clearance and incidence of high-risk HPV infection; and persistence, progression, regression, cure and incidence of cervical dysplasia. RESULTS Among 300 women screened at baseline, 237 attended follow up (79%). High-risk HPV positivity significantly decreased from 28% at baseline to 20% at 1 year (P = 0.02). High-risk HPV persistence was 46% and clearance was 54%; incidence was high at 9%. Prevalence of cervical intraepithelial neoplasia Grade 2 (CIN2) or higher was most common in participants with incident high-risk HPV (53%). CIN2 or higher was also common in those with persistent high-risk HPV (32%) and even in those who cleared high-risk HPV (30%). Of the high-risk HPV-positive participants at baseline with |
| Databáze: | OpenAIRE |
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