A prospective, comparative study of severe neurological and uncomplicated hand, foot and mouth forms of paediatric enterovirus 71 infections
| Autor: | Paul F. Horwood, Veasna Duong, Yoann Crabol, Philippe Dussart, Channa Mey, Polidy Pean, Heng Sothy, Denis R. St. Laurent, Philippe Buchy, Beat Richner, Arnaud Tarantola, Ky Santy |
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| Přispěvatelé: | Unité d'Épidémiologie et de Santé Publique, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Réseau International des Instituts Pasteur (RIIP), Unité de Virologie, Kantha Bopha Hospitals Foundation, GlaxoSmithKline, Unité d'Épidémiologie et de Santé Publique [Phnom Penh], Unité de Virologie / Virology Unit [Phnom Penh] |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine encephalitis hand foot and mouth disease Disease Disease Outbreaks Pulmonary oedema pulmonary oedema Risk Factors MESH: Risk Factors [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Child Enterovirus 71 Medicine Encephalitis Viral Prospective Studies MESH: Disease Outbreaks Child MESH: Hand Foot and Mouth Disease biology General Medicine MESH: Encephalitis Viral 3. Good health Infectious Diseases medicine.anatomical_structure MESH: Enterovirus A Human Child Preschool [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Female Cambodia Foot (unit) Encephalitis Microbiology (medical) medicine.medical_specialty Adolescent lcsh:Infectious and parasitic diseases 03 medical and health sciences Throat Internal medicine Humans lcsh:RC109-216 In patient Intensive care medicine MESH: Adolescent [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics MESH: Humans business.industry MESH: Cambodia MESH: Child Preschool Serum samples biology.organism_classification medicine.disease MESH: Male MESH: Prospective Studies Enterovirus A Human EV-A71 030104 developmental biology Hand Foot and Mouth Disease business MESH: Female |
| Zdroj: | International Journal of Infectious Diseases International Journal of Infectious Diseases, Elsevier, 2017, 59, pp.69-76. ⟨10.1016/j.ijid.2017.04.005⟩ International Journal of Infectious Diseases, Vol 59, Iss C, Pp 69-76 (2017) |
| ISSN: | 1201-9712 1878-3511 |
| Popis: | Objectives In this study, we document the clinical characteristics and investigated risk factors for uncomplicated and severe forms of EV-A71 disease in Cambodian children. Methods From March to July 2014 inclusive, all patients with suspicion of EV-A71 infection presenting to Kantha Bopha Hospitals in Phnom Penh and Siem Reap and confirmed by the Virology Unit at the Institut Pasteur du Cambodge were prospectively enrolled in this study. Throat swabs, rectal swabs and serum samples were collected from all consecutive patients with suspected EV-A71 infection. In addition, CSF was also collected from patients with suspected EV-A71 associated encephalitis. A total of 122 patients (29 with uncomplicated disease and 93 with severe disease) with confirmed EV-A71 infection with all available demographic and clinical data for clinical classification and further analysis were included in the study. Results In this prospective EV-A71 study in Cambodia, we confirmed the previously reported association of male gender and absence of mouth or skin lesions with severe disease. We also highlighted the strong association of neutrophils in blood, but also in CSF in patients with pulmonary oedema. More importantly, we identified new putative nutrition-related risk factors for severe disease. Conclusions EV-A71 is an important cause of encephalitis in the Asia-Pacific region. Further studies to determine the risk factors associated with severe EV-A71 disease are needed. |
| Databáze: | OpenAIRE |
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