Wnt Signaling: Role in Regulation of Haematopoiesis
Autor: | Usha Gutti, Satya Ratan Pasupuleti, Shilpa Sarvothaman, Itishri Sahu, Ravi Kumar Gutti, Ravinder Kandi, Ram Babu Undi |
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Rok vydání: | 2014 |
Předmět: |
0301 basic medicine
education.field_of_study business.industry Population Wnt signaling pathway LRP6 LRP5 Hematology Review Article Cell fate determination Cell biology 03 medical and health sciences Haematopoiesis 030104 developmental biology Medicine Signal transduction Stem cell education business |
Zdroj: | Indian journal of hematologyblood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion. 32(2) |
ISSN: | 0971-4502 |
Popis: | Hematopoietic stem cells (HSCs) are a unique population of bone marrow cells which are responsible for the generation of various blood cell lineages. One of the significant characteristics of these HSCs is to self-renew, while producing differentiating cells for normal hematopoiesis. Deregulation of self-renewal and differentiation leads to the hematological malignancies. Several pathways are known to be involved in the maintenance of HSC fate among which Wnt signaling is a crucial pathway which controls development and cell fate determination. Wnt signaling also plays a major role in differentiation, self-renewal and maintenance of HSCs. Wnt ligands activate three major pathways including planar cell polarity, Wnt/β-catenin and Wnt/Ca(2+). It has been shown that Wnt/β-catenin or canonical pathway regulates cell proliferation, survival and differentiation in HSCs, deregulation of this pathway leads to hematological malignancies. Wnt non-canonical pathway regulates calcium signaling and planar cell polarity. In this review, we discuss various signaling pathways induced by Wnt ligands and their potential role in hematopoiesis. |
Databáze: | OpenAIRE |
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