Recovery of cefazolin and clindamycin in in vitro pediatric CPB systems
| Autor: | Enno D. Wildschut, Fritz Soergel, Gerdien A Zeilmaker-Roest, Dick Tibboel, Joost van Rosmalen, Martina Kinzig, Marloes P J van Hoeven, Birgit C. P. Koch, Robert Jan Stolker, Annewil van Saet, Ad J.J.C. Bogers |
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| Přispěvatelé: | Cardiothoracic Surgery, Pediatric Surgery, Anesthesiology, Pharmacy, Epidemiology |
| Rok vydání: | 2019 |
| Předmět: |
Heart Defects
Congenital medicine.medical_specialty medicine.drug_class 0206 medical engineering Antibiotics Medizin Biomedical Engineering Cefazolin Medicine (miscellaneous) Bioengineering 02 engineering and technology 030204 cardiovascular system & hematology Pediatrics antibiotics law.invention Biomaterials neonatal 03 medical and health sciences 0302 clinical medicine Pharmacokinetics law Main Text Articles medicine Cardiopulmonary bypass Humans Cardiopulmonary Bypass Main Text Article business.industry Clindamycin Significant difference in vitro sequestration General Medicine Plasma levels 020601 biomedical engineering infant Cardiac surgery Anti-Bacterial Agents surgical procedures operative pediatric Anesthesia business medicine.drug |
| Zdroj: | Artificial Organs Artificial Organs, 44, 394-401. Wiley-Blackwell Publishing Ltd |
| ISSN: | 1525-1594 0160-564X |
| Popis: | Cardiopulmonary bypass (CPB) is often necessary for congenital cardiac surgery, but CPB can alter drug pharmacokinetic parameters resulting in underdosing. Inadequate plasma levels of antibiotics could lead to postoperative infections with increased morbidity. The influence of pediatric CPB systems on cefazolin and clindamycin plasma levels is not known. We have measured plasma levels of cefazolin and clindamycin in in vitro pediatric CPB systems. We have tested three types of CPB systems. All systems were primed and spiked with clindamycin and cefazolin. Samples were taken at different time points to measure the recovery of cefazolin and clindamycin. Linear mixed model analyses were performed to assess if drug recovery was different between the type of CPB system and sampling time point. The experiments were conducted at a tertiary university hospital. 81 samples were analyzed. There was a significant difference in the recovery over time between CPB systems for cefazolin and clindamycin (P |
| Databáze: | OpenAIRE |
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