Platelet glycoprotein IIb/IIIa (HPA-1 and HPA-3) polymorphisms in patients with hemorrhagic fever with renal syndrome
| Autor: | Maicang Gao, Qunying Han, Jie Fang, Zhengwen Liu, Sai Lou |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Platelet Membrane Glycoprotein IIb endocrine system Adolescent Immunology Biology Polymorphism Single Nucleotide Young Adult Antigen Gene Frequency Genotype Immunology and Allergy Humans Platelet Antigens Human Platelet Genetic Predisposition to Disease Allele Genotyping Allele frequency Hantaan virus Aged Integrin beta3 virus diseases General Medicine Middle Aged Hemorrhagic Fever with Renal Syndrome Female Hantavirus Infection hormones hormone substitutes and hormone antagonists |
| Zdroj: | Human immunology. 70(6) |
| ISSN: | 1879-1166 |
| Popis: | This study investigated the relationship between human platelet alloantigen (HPA) polymorphisms of glycoprotein IIb/IIIa and hemorrhagic fever with renal syndrome (HFRS). HPA-1 and HPA-3 genotyping was performed with allele-specific primer polymerase chain reaction in 104 patients with HFRS and 100 normal individuals as controls. The relationships between gene polymorphisms of HPAs and HFRS and the disease severity were analyzed. The results indicated no significant difference in HPA-1 genotype distributions (p > 0.05), but a significant difference in the distributions of genotype and allele frequencies of HPA-3 between HFRS patients and controls (p < 0.01). The distributions of HPA-3 genotype and allele frequencies differed significantly between patients with different clinical types and the HPA-3 b allele was more frequently observed in patients with more severe clinical types. These results indicate that HPA-3 polymorphism may be one of the inherited risk factors associated with the susceptibility of hantavirus infection and the disease severity of HFRS. |
| Databáze: | OpenAIRE |
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