An amino acid polymorphism in histidine-rich glycoprotein (HRG) explains 59% of the variance in plasma HRG levels
| Autor: | B.C. Hennis, Dorret I. Boomsma, G. Dooijewaard, P.A. van Boheemen, L. Engesser, P. Kievit, Cornelis Kluft |
|---|---|
| Přispěvatelé: | TNO Preventie en Gezondheid, Biological Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
glycoprotein
Netherlands Twin Register (NTR) maximum likelihood method Histidine-rich glycoprotein Locus (genetics) Biology blood level environmental factor Blood plasma genetic polymorphism inheritance Humans controlled study human normal human Allele Amino Acids Alleles Glycoproteins Genetics chemistry.chemical_classification Analysis of Variance Likelihood Functions Polymorphism Genetic adult article pedigree Chromosome Mapping Proteins Hematology Blood Proteins Heritability histidine Blood proteins Phenotype major clinical study Molecular Weight chemistry age priority journal Case-Control Studies Glycoprotein |
| Zdroj: | Hennis, B C, Boomsma, D I, van Boheemen, P A, Engesser, L, de Kievit, P, Dooijewaard, G & Kluft, C 1995, ' An amino acid polymorphism in histidine-rich glycoprotein (HRG) explains 59% of the variance in plasma HRG levels ', Thrombosis and Haemostasis, vol. 74, no. 6, pp. 1497-1500 . < http://www.tweelingenregister.org/nederlands/verslaggeving/NTR_publicaties/amino%20acid%20polymorphism_hennis_1995.pdf > Thrombosis and Haemostasis, 74(6), 1497-1500. Schattauer GmbH Thrombosis and Haemostasis, 6, 74, 1497-1500 |
| ISSN: | 0340-6245 |
| Popis: | SummaryA pedigree-based maximum likelihood method developed by Lange et al. (12) was used to study the contribution of a newly defined di-allelic polymorphism in histidine-rich glycoprotein (HRG) to the plasma levels of HRG. In four families (n = 99) and 20 volunteers we found a heritability of 70%, an age effect of 3% and an effect of individual environmental factors of 27%. These results are remarkably similar to the results found in a previous parent-twin study in which a heritability of 69% and an effect of random environment of 31% was found. The overall genetic influence in the present study can be subdivided into an effect of 59% by the HRG phenotype and 11% by residual genetic factors. The influence of the HRG phenotype of 59% can entirely be explained by adding up the effect of the two alleles that make up the phenotype. These results indicate a codominant inheritance pattern of HRG levels in which the genetic influence can almost completely be ascribed to the additive effect of the di-allelic HRG locus whereas only a small part is due to other loci. |
| Databáze: | OpenAIRE |
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