SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks
| Autor: | Orsolya Liska, Máté Varga, Peter Csermely, Oyebode James Oyeyemi, Balázs Bohár, Mihaly Koltai, Bernadette Hotzi, Illés J Farkas, Kitti Csályi, Dávid Fazekas, Luca Csabai, Amanda Demeter, Tamas Korcsmaros, Marton Olbei, Nóra Pápai, Máté Szalay-Bekő, Eszter Ari, Dénes Türei, Viktor Billes, Eszter Molnár, László Földvári-Nagy, Tibor Vellai, Dezső Módos, János Kubisch, Katalin Lenti, M Madgwick, Lejla Gul, Padhmanand Sudhakar, Tamás Kadlecsik |
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| Jazyk: | angličtina |
| Předmět: |
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AcademicSubjects/SCI00010 05 Environmental Sciences Danio Computational biology 03 medical and health sciences 0302 clinical medicine Resource (project management) Databases Genetic Genetics Animals Humans Database Issue Gene Regulatory Networks Protein Interaction Maps Caenorhabditis elegans Zebrafish 030304 developmental biology computer.programming_language 0303 health sciences biology 06 Biological Sciences Complex network biology.organism_classification Drosophila melanogaster Homo sapiens 08 Information and Computing Sciences Signal transduction computer 030217 neurology & neurosurgery Developmental Biology Signal Transduction |
| Zdroj: | Nucleic Acids Research D709 D701 |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gkab909 |
| Popis: | Signaling networks represent the molecular mechanisms controlling a cell's response to various internal or external stimuli. Most currently available signaling databases contain only a part of the complex network of intertwining pathways, leaving out key interactions or processes. Hence, we have developed SignaLink3 (http://signalink.org/), a value-added knowledge-base that provides manually curated data on signaling pathways and integrated data from several types of databases (interaction, regulation, localisation, disease, etc.) for humans, and three major animal model organisms. SignaLink3 contains over 400 000 newly added human protein-protein interactions resulting in a total of 700 000 interactions for Homo sapiens, making it one of the largest integrated signaling network resources. Next to H. sapiens, SignaLink3 is the only current signaling network resource to provide regulatory information for the model species Caenorhabditis elegans and Danio rerio, and the largest resource for Drosophila melanogaster. Compared to previous versions, we have integrated gene expression data as well as subcellular localization of the interactors, therefore uniquely allowing tissue-, or compartment-specific pathway interaction analysis to create more accurate models. Data is freely available for download in widely used formats, including CSV, PSI-MI TAB or SQL. ispartof: NUCLEIC ACIDS RESEARCH vol:50 issue:D1 pages:D701-D709 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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