Apolipoprotein D
| Autor: | Eric Rassart, Frederik Desmarais, Ouafa Najyb, Karl-F. Bergeron, Catherine Mounier |
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| Rok vydání: | 2020 |
| Předmět: |
2. Zero hunger
0303 health sciences Embryonic Development Neurodegenerative Diseases General Medicine Nervous System Article 03 medical and health sciences 0302 clinical medicine Organ Specificity Neoplasms Genetics Animals Humans Apolipoproteins D 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Gene |
| ISSN: | 1879-0038 |
| Popis: | ApoD is a 25 to 30 kDa glycosylated protein, member of the lipocalin superfamily. As a transporter of several small hydrophobic molecules, its known biological functions are mostly associated to lipid metabolism and neuroprotection. ApoD is a multi-ligand, multi-function protein that is involved lipid trafficking, food intake, inflammation, antioxidative response and development and in different types of cancers. An important aspect of ApoD’s role in lipid metabolism appears to involve the transport of arachidonic acid, and the modulation of eicosanoid production and delivery in metabolic tissues. ApoD expression in metabolic tissues has been associated positively and negatively with insulin sensitivity and glucose homeostasis in a tissue dependent manner. ApoD levels rise considerably in association with aging and neuropathologies such as Alzheimer’s disease, stroke, meningoencephalitis, moto-neuron disease, multiple sclerosis, schizophrenia and Parkinson’s disease. ApoD is also modulated in several animal models of nervous system injury/pathology. |
| Databáze: | OpenAIRE |
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