Serotonin transporter gene and adverse life events in adult ADHD
| Autor: | Pierandrea Muglia, Umesh Jain, James L. Kennedy, Daniel J. Müller, Tricia Sicard, Diana De Ronchi, Laura Mandelli, Alessandro Serretti, Subi Tharmalingam, Vincenzo De Luca, Colin G. DeYoung, Jürgen Gallinat |
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| Přispěvatelé: | Muller D.J., Mandelli L., Serretti A., Deyoung C.G., De Luca V., Sicard T., Tharmalingam S., Gallinat J., Muglia P., De Ronchi D., Jain U., Kennedy J.L. |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Adolescent Genotype Poison control Catechol O-Methyltransferase Severity of Illness Index behavioral disciplines and activities Life Change Events Young Adult Cellular and Molecular Neuroscience mental disorders Injury prevention medicine Humans Attention deficit hyperactivity disorder Promoter Regions Genetic Adverse effect Gene Genetics (clinical) Serotonin transporter Serotonin Plasma Membrane Transport Proteins Norepinephrine Plasma Membrane Transport Proteins Polymorphism Genetic biology business.industry Stressor Life events Middle Aged medicine.disease Psychiatry and Mental health Norepinephrine transporter Attention Deficit Disorder with Hyperactivity biology.protein Etiology Regression Analysis Female business Clinical psychology |
| Zdroj: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :1461-1469 |
| ISSN: | 1552-485X 1552-4841 |
| Popis: | Childhood attention deficit hyperactivity disorder (ADHD) symptomatology persists in a substantial proportion of cases into adult life. ADHD is highly heritable but the etiology of ADHD is complex and heterogeneous, involving both genetic and non-genetic factors. In the present article we analyzed the influence of both genetics and adverse life events on severity of ADHD symptoms in 110 adult ADHD patients. Subjects were genotyped for the norepinephrine transporter (NET), the catechol-O-methyltransferase (COMT), the serotonin transporter promoter polymorphism (SERTPR) and the more rare A/G variant within SERTPR. Three main outcomes were obtained: (1) adverse events showed a small but positive correlation with current ADHD severity; (2) NET, COMT and the A/G variant within SERTPR were not associated with ADHD severity; (3) taking into account stressors, the long (L) SERTPR variant showed a mild effect on ADHD, being associated with an increased severity, particularly as regard affective dysregulations; on the other hand, in subjects exposed to early stressors, it showed a protective effect, as compared to the short (S) variant. In conclusion, our data support the role of environmental factors in adult ADHD symptomatology. SERTPR may be involved in some features of the illness and act as a moderator of environmental influences in ADHD. © 2008 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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