Cell adhesion molecules regulate Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3
| Autor: | Katsuhiko Mikoshiba, Hiroyuki Kamiguchi, Fumie Yoshihara, Akira Futatsugi, Noriko Ooashi |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
animal structures
Growth Cones Chick Embryo Biology Article Mice Dorsal root ganglion Ganglia Spinal Cyclic AMP medicine Animals Calcium Signaling Growth cone Protein kinase A Research Articles Cells Cultured Calcium signaling Cell adhesion molecule Ryanodine receptor Ryanodine Receptor Calcium Release Channel Cell Biology Cyclic AMP-Dependent Protein Kinases Cell biology Cytosol medicine.anatomical_structure Calcium Neuron Cell Adhesion Molecules |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| DOI: | 10.1083/jcb.200503157 |
| Popis: | Axonal growth cones migrate along the correct paths during development, not only directed by guidance cues but also contacted by local environment via cell adhesion molecules (CAMs). Asymmetric Ca2+ elevations in the growth cone cytosol induce both attractive and repulsive turning in response to the guidance cues (Zheng, J.Q. 2000. Nature. 403:89–93; Henley, J.R., K.H. Huang, D. Wang, and M.M. Poo. 2004. Neuron. 44:909–916). Here, we show that CAMs regulate the activity of ryanodine receptor type 3 (RyR3) via cAMP and protein kinase A in dorsal root ganglion neurons. The activated RyR3 mediates Ca2+-induced Ca2+ release (CICR) into the cytosol, leading to attractive turning of the growth cone. In contrast, the growth cone exhibits repulsion when Ca2+ signals are not accompanied by RyR3-mediated CICR. We also propose that the source of Ca2+ influx, rather than its amplitude or the baseline Ca2+ level, is the primary determinant of the turning direction. In this way, axon-guiding and CAM-derived signals are integrated by RyR3, which serves as a key regulator of growth cone navigation. |
| Databáze: | OpenAIRE |
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