Unaltered pharmacokinetics after the administration of high-dose etoposide without prior dilution
| Autor: | Gerhard Ehninger, P. Waidelich, Roland Dopfer, B. Proksch, B. Eichel, H. Schmidt |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Cancer Research Adolescent medicine.medical_treatment Biological Availability Pharmacology Toxicology Pharmacokinetics Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Pharmacology (medical) Infusions Intravenous Saline Chromatography High Pressure Liquid Etoposide Bone Marrow Transplantation Volume of distribution business.industry Radiotherapy Dosage Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Combined Modality Therapy Dilution Bioavailability Leukemia medicine.anatomical_structure Oncology Leukemia Myeloid Acute Disease Bone marrow business medicine.drug |
| Zdroj: | Cancer Chemotherapy and Pharmacology. 28:214-216 |
| ISSN: | 1432-0843 0344-5704 |
| DOI: | 10.1007/bf00685512 |
| Popis: | The pharmacokinetics of etoposide following a new method of administration was determined. Undiluted etoposide was given at a dose of 30 mg/kg as part an intensified conditioning regimen prior to bone marrow transplantation. A terminal half-life of 3.4 +/- 0.7 h and a volume of distribution of 15.4 +/- 9.6 l were found (n = 8); the AUC was 764 +/- 302 micrograms h ml-1. As compared with those obtained in other pharmacokinetic studies using etoposide diluted in normal saline, our data reflect full systemic bioavailability and unaltered pharmacokinetics. The application of undiluted etoposide makes the therapy easier and less time-consuming and avoids a high fluid volume and a high saline load. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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