Meta-Analysis of Outcomes of Transcatheter Aortic Valve Implantation Among Patients With Low Gradient Severe Aortic Stenosis
| Autor: | Fahad Alqahtani, Yasir Abdul Ghaffar, Babikir Kheiri, Mohammed Osman, Khansa Osman, Tianne J. Foster, Kuldeep Shah, Mohamad Alkhouli |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Ejection fraction Transcatheter aortic business.industry Stroke Volume Aortic Valve Stenosis Stroke volume 030204 cardiovascular system & hematology medicine.disease Transcatheter Aortic Valve Replacement 03 medical and health sciences Stenosis 0302 clinical medicine Meta-analysis Internal medicine medicine Cardiology Humans In patient 030212 general & internal medicine Low gradient Cardiology and Cardiovascular Medicine business Cardiovascular mortality |
| Zdroj: | The American Journal of Cardiology. 124:423-429 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2019.05.006 |
| Popis: | Transcatheter aortic valve implantation (TAVI) has emerged as an effective therapy for patients with severe aortic stenosis (AS). However, data on TAVI outcomes in patients with low gradient (LG) AS are limited. We performed a meta-analysis of studies comparing TAVI outcomes between patients with classic high gradient (HG) and LG AS through November 2018. The 30-day mortality, mid-term all-cause, and cardiovascular mortality at maximum follow-up were compared between patients with HG and LG AS (Pairwise meta-analysis), and between the three distinct groups of AS including HG, paradoxical low-flow low-gradient and low gradient with reduced ejection fraction (rEF-LG) (Network meta-analysis). Nineteen studies (n = 27,204 patients) met the inclusion criteria. The HG group had less 30-day, mid-term all-cause and cardiovascular mortality compared with the low-gradient AS group overall, (6% vs 7.5%, OR 0.76, 95% CI 0.66 to 0.87, I2 = 18%), (21% vs 29%, OR 0.59, 95% CI 0.52 to 0.67, I2 = 62%), and (12.6% vs 18.7%, OR 0.61, 95% CI 0.49 to 0.76, I2 = 62%), respectively, p |
| Databáze: | OpenAIRE |
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