Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa
| Autor: | Sylvian Cretton, Yvan Vander Heyden, Amélia T. Henriques, André Luís de Gasper, Luiz C. Klein-Junior, Philippe Christen, Samad Nejad-Ebrahimi |
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| Přispěvatelé: | Analytical Chemistry and Pharmaceutical Technology, Pharmaceutical and Pharmacological Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Indole test β carboline derivatives biology Traditional medicine 010405 organic chemistry Chemistry Alkaloid Organic Chemistry Pharmaceutical Science biology.organism_classification 01 natural sciences 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine Phytochemical Drug Discovery Molecular Medicine Psychotria Azepine |
| Popis: | Phytochemical investigation of the alkaloid extract of the aerial parts of Psychotria nemorosa led to the isolation and characterization of 10 azepine-indole alkaloids, i.e., cimitrypazepine (1), fargesine (2), nemorosines A (3), and B (12), nemorosinosides A-F (4-9), as well as two β-carboline derivatives, 10-hydroxyisodolichantoside (10) and 10-hydroxydolichantoside (11), an isoxazole alkaloid, nemorosinoside G (13), serotonin (14), bufotenine (15), and (S)-gentianol (16). Compounds 3-13 have not yet been described. These compounds were isolated by semipreparative HPLC, and their structures were determined by means of HRMS, NMR, and ECD measurements. In addition, the monoamine oxidase-A (MAO-A), MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory activities were evaluated. Alkaloids 1-3 inhibited the MAO-A activity with IC50 values of 1.4, 1.4, and 0.9 μM, respectively. |
| Databáze: | OpenAIRE |
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