Possible protective effects of docosahexaenoic acid (DHA) in combined prenatal exposure to methylmercury and long chain polyunsaturated fatty acids (LCPUFA)
| Autor: | Jelena Radić Nišević, Petar Vukelić, Milena Horvat, Igor Prpić, Zdravko Špirić |
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| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Chemistry Prenatal exposure long-chain polyunsaturated fatty acids General Medicine chemistry.chemical_compound Endocrinology Docosahexaenoic acid Internal medicine Pediatrics Perinatology and Child Health medicine Neurology (clinical) Prenatal exposure Long chain Methylmercury Polyunsaturated fatty acid |
| Zdroj: | European Journal of Paediatric Neurology. 21:e68 |
| ISSN: | 1090-3798 |
| DOI: | 10.1016/j.ejpn.2017.04.1164 |
| Popis: | Objective: Prenatal exposure to long-chain polyunsaturated fatty acids (LCPUFA) is essential for normal fetal growth and neurodevelopment. Availability of LCPUFA depends mostly on maternal fish consumption which also exposes the fetus to the methylmercury (MeHg). MeHg is neurotoxicant whose prenatal low-level can affect long-term child neurodevelopment, which are considered to be mediated by oxidative damage and consequently inflammation. However, the impact of combined LCPUFA and MeHg from fish consumption during pregnancy may lead to contradictory influences on child development outcomes. Depending on which particular LCPUFA are present in the diet, neuroinflammation will, therefore, be kept at a minimum or exacerbated. We hypothesized that prenatal exposure LCPUFA through mother's consumption of fish can overcome or mask the effect of prenatal exposure to MeHg which would have potential protective effects in children with higher levels of MeHg. |
| Databáze: | OpenAIRE |
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