Ventricular wall stress and wall shear stress homeostasis predicts cardiac remodeling during pregnancy: A modeling study
Autor: | Comunale, Giulia, Susin, Francesca M, Mynard, Jonathan P. |
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Rok vydání: | 2021 |
Předmět: |
Cardiac function curve
cardiovascular modeling medicine.medical_specialty Heart Ventricles Biomedical Engineering Hemodynamics cardiac remodeling lumped parameter models pregnancy Stress (mechanics) Internal medicine Shear stress Homeostasis Humans Medicine Molecular Biology Pregnancy Fetus Ventricular Remodeling business.industry Applied Mathematics Heart medicine.disease Computational Theory and Mathematics Modeling and Simulation Cardiology Gestation Female business Software |
Zdroj: | International Journal for Numerical Methods in Biomedical Engineering. 38 |
ISSN: | 2040-7947 2040-7939 |
Popis: | Pregnancy is a unique and dynamic process characterized by significant changes in the maternal cardiovascular system that are required to satisfy the increased maternal and fetal metabolic demands. Profound structural and hemodynamic adaptations occur during healthy pregnancy that allows the mother to maintain healthy hemodynamics and provide an adequate uteroplacental blood circulation to ensure physiological fetal development. Investigating these adaptations is crucial for understanding the physiology of pregnancy and may provide important insights for the management of high-risk pregnancies. However, no previous modeling studies have investigated the maternal cardiac structural changes that occur during gestation. This study, therefore, had two aims. The first was to develop a lumped parameter model of the whole maternal circulation that is suitable for studying global hemodynamics and cardiac function at different stages of gestation. The second was to test the hypothesis that myofiber stress and wall shear stress homeostasis principles can be used to predict cardiac remodeling that occurs during normal pregnancy. Hemodynamics and cardiac variables predicted from simulations with and without controlled cardiac remodeling algorithms were compared and evaluated with reference clinical data. While both models reproduced the hemodynamic variations that arise in pregnancy, importantly, we show that the structural changes that occur with pregnancy could be predicted by assuming invariant homeostatic "target" values of myocardial wall stress and chamber wall shear stress. |
Databáze: | OpenAIRE |
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