Cardiac structure and function in youth with type 2 diabetes in the iCARE cohort study: Cross‐sectional associations with prenatal exposure to diabetes and metabolomic profiles
| Autor: | Elizabeth Sellers, Brandy Wicklow, Todd A. Duhamel, Jonathan McGavock, Joseph W. Gordon, Jinelle C. Gelinas, Allison Dart, Davinder S. Jassal, Neil D. Eves, Laetitia Guillemette, Robert Balshaw, Vernon W. Dolinsky, Prasoon Agarwal, David Cheung |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Heart disease Endocrinology Diabetes and Metabolism Diastole 030209 endocrinology & metabolism Type 2 diabetes Carotid Intima-Media Thickness Ventricular Function Left Ventricular Dysfunction Left Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Diabetes mellitus Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine Glycemic business.industry Heart medicine.disease 3. Good health Cross-Sectional Studies Diabetes Mellitus Type 2 Intima-media thickness Echocardiography In utero Case-Control Studies Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Cardiology Female Carotid artery structure business Amino Acids Branched-Chain |
| Zdroj: | Pediatric Diabetes. 21:233-242 |
| ISSN: | 1399-5448 1399-543X |
| DOI: | 10.1111/pedi.12954 |
| Popis: | Objective This study aimed to determine the degree of left ventricular (LV) dysfunction and its determinants in adolescents with type 2 diabetes (T2D). We hypothesized that adolescents with T2D would display impaired LV diastolic function and that these cardiovascular complications would be exacerbated in youth exposed to maternal diabetes in utero. Methods Left ventricular structure and function, carotid artery intima media thickness and strain, and serum metabolomic profiles were compared between adolescents with T2D (n = 121) and controls (n = 34). Sub-group analyses examined the role of exposure to maternal diabetes as a determinant of LV or carotid artery structure and function among adolescents with T2D. Results Adolescents with T2D were 15.1 ± 2.5 years old, (65% female, 99% Indigenous), had lived with diabetes for 2.7 ± 2.2 years, had suboptimal glycemic control (HbA1c = 9.4 ± 2.6%) and 58% (n = 69) were exposed to diabetes in utero. Compared to controls, adolescents with T2D displayed lower LV diastolic filling (early diastole/atrial filling rate ratio [E/A] = 1.9 ± 0.6 vs 2.2 ± 0.6, P = 0.012), lower LV relaxation and carotid strain (0.12 ± 0.05 vs 0.17 ± 0.05, P = .03) and elevated levels of leucine, isoleucine and valine. Among adolescents with T2D, exposure to diabetes in utero was not associated with differences in LV diastolic filling, LV relaxation, carotid strain or branched chain amino acids. Conclusions Adolescents with T2D display LV diastolic dysfunction, carotid artery stiffness, and elevated levels of select branch chain amino acids; differences were not associated with exposure to maternal diabetes in utero. |
| Databáze: | OpenAIRE |
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