Synthesis and biological evaluation of a series of fatty acid amides from Echinacea
Autor: | Travis V. Gulledge, Yasamin Moazami, Scott M. Laster, Joshua G. Pierce |
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Rok vydání: | 2015 |
Předmět: |
Lipopolysaccharides
medicine.drug_class Clinical Biochemistry Pharmaceutical Science Pharmacology Biochemistry Echinacea Anti-inflammatory Cell Line Mice Echinacea (animal) Drug Discovery medicine Animals Molecular Biology Biological evaluation chemistry.chemical_classification Traditional medicine biology Plant Extracts Tumor Necrosis Factor-alpha Macrophages Fatty Acids Organic Chemistry Fatty acid biology.organism_classification Amides chemistry Molecular Medicine |
Zdroj: | Bioorganic & Medicinal Chemistry Letters. 25:3091-3094 |
ISSN: | 0960-894X |
Popis: | Alkylamides are lipophilic constituents of Echinacea and possess numerous biological activities. Although significant effort has been focused on the study of crude Echinacea extracts, very little is known regarding the activities of the individual constituents that make up these herbal treatments. Herein we explore the SAR of simple alkylamides found in Echinacea extracts with respect to their ability to decrease the production of the pro-inflammatory mediator TNF-α. Our results have revealed the key structural requirements for activity and provide lead compounds for further investigation of these poorly understood molecules. |
Databáze: | OpenAIRE |
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