European surveillance of emerging pathogens associated with canine infectious respiratory disease

Autor: Mitchell, Judy A, Cardwell, Jacqueline M, Leach, Heather, Walker, Caray A, Le Poder, Sophie, Decaro, Nicola, Rusvai, Miklos, Egberink, Herman, Rottier, Peter, Fernandez, Mireia, Fragkiadaki, Eirini, Shields, Shelly, Brownlie, Joe, dI&I I&I-1, LS Klinisch Onderzoek Wagenaar, LS Virologie, dI&I I&I-4
Přispěvatelé: Royal Veterinary College - University of London, Virologie UMR1161 (VIRO), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Department of Veterinary Medicine, University of Cambridge [UK] (CAM), Department of Pathology, University of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University [Utrecht], Universitat Autònoma de Barcelona (UAB), Faculty of Animal Science and Aquaculture, Agricultural University of Athens, Zoetis, Zoetis Animal Health, Petplan Charitable Trust, dI&I I&I-1, LS Klinisch Onderzoek Wagenaar, LS Virologie, dI&I I&I-4
Rok vydání: 2017
Předmět:
0301 basic medicine
Disease occurrence
Canine pneumovirus (CnPnV)
Communicable Diseases
Emerging
0403 veterinary science
Mycoplasma cynos
Mycoplasma
Coronavirus
Canine
Prevalence
Dog Diseases
Respiratory Tract Infections
biology
Respiratory disease
04 agricultural and veterinary sciences
General Medicine
Canine influenza (CIV)
3. Good health
Europe
Influenza A virus
Epidemiological Monitoring
Antibody
Coronavirus Infections
Kennel cough
040301 veterinary sciences
Microbiology
Article
Virus
03 medical and health sciences
Dogs
Orthomyxoviridae Infections
medicine
Animals
Pneumovirus Infections
Mycoplasma Infections
Canine respiratory coronavirus (CRCoV)
Canine pneumovirus
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
Pneumovirus
General Veterinary
Canine distemper
business.industry
medicine.disease
Virology
030104 developmental biology
Immunology
biology.protein
Canine infectious respiratory disease (CIRD)
business
Zdroj: Veterinary Microbiology
Veterinary Microbiology, Elsevier, 2017, 212, pp.31-38. ⟨10.1016/j.vetmic.2017.10.019⟩
Veterinary Microbiology, 212, 31. Elsevier
VETERINARY MICROBIOLOGY
ISSN: 0378-1135
DOI: 10.1016/j.vetmic.2017.10.019
Popis: Highlights • The largest study of its kind in the field to date, including high-risk kennelled dogs, and for the first time, pet dogs and dogs from other cohorts. • A clearly identifiable link between disease and the emerging pathogens: canine respiratory coronavirus and canine pneumovirus. • Provides, substantial evidence of CIRD and the circulation of the novel pathogens studied in pet dogs, and dogs from other cohorts. • Demonstrates the role and limitations of current vaccine strategies in managing CIRD outbreaks, and the need for including emerging pathogens.
Canine infectious respiratory disease (CIRD) is a major cause of morbidity in dogs worldwide, and is associated with a number of new and emerging pathogens. In a large multi-centre European study the prevalences of four key emerging CIRD pathogens; canine respiratory coronavirus (CRCoV), canine pneumovirus (CnPnV), influenza A, and Mycoplasma cynos (M. cynos); were estimated, and risk factors for exposure, infection and clinical disease were investigated. CIRD affected 66% (381/572) of the dogs studied, including both pet and kennelled dogs. Disease occurrence and severity were significantly reduced in dogs vaccinated against classic CIRD agents, canine distemper virus (CDV), canine adenovirus 2 (CAV-2) and canine parainfluenza virus (CPIV), but substantial proportions (65.7%; 201/306) of vaccinated dogs remained affected. CRCoV and CnPnV were highly prevalent across the different dog populations, with overall seropositivity and detection rates of 47% and 7.7% for CRCoV, and 41.7% and 23.4% for CnPnV, respectively, and their presence was associated with increased occurrence and severity of clinical disease. Antibodies to CRCoV had a protective effect against CRCoV infection and more severe clinical signs of CIRD but antibodies to CnPnV did not. Involvement of M. cynos and influenza A in CIRD was less apparent. Despite 45% of dogs being seropositive for M. cynos, only 0.9% were PCR positive for M. cynos. Only 2.7% of dogs were seropositive for Influenza A, and none were positive by PCR.
Databáze: OpenAIRE
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