Cranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Age
| Autor: | Karl C. K. Kuban, Nigel Paneth, Olaf Dammann, Stephen C. Engelke, Sjirk J. Westra, Padmani Karna, Elaine Romano, Cindy R. Miller, Adré J. du Plessis, Cecelia Keller, Elizabeth N. Allred, Marcello Pagano, Kalpathy S. Krishnamoorthy, Alan Leviton, Joseph Junewick, Daniel G. Batton, Haim Bassan, Sunila E. O'Connor, T. Michael O'Shea, Nicholas Olomu, Joanna J. Seibert |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Developmental Disabilities Motor Activity Article Cerebral palsy Cohort Studies White matter Intensive Care Units Neonatal Confidence Intervals medicine Humans Prospective cohort study Cerebral Hemorrhage Ultrasonography Neurologic Examination medicine.diagnostic_test business.industry Cerebral Palsy Infant Newborn Gestational age Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Surgery Intraventricular hemorrhage Hemiparesis medicine.anatomical_structure Infant Extremely Low Birth Weight Child Preschool Pediatrics Perinatology and Child Health Female Neurology (clinical) medicine.symptom business Head Psychomotor Performance Ventriculomegaly |
| Zdroj: | Journal of Child Neurology. 24:63-72 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/0883073808321048 |
| Popis: | Our prospective cohort study of extremely low gestational age newborns evaluated the association of neonatal head ultrasound abnormalities with cerebral palsy at age 2 years. Cranial ultrasounds in 1053 infants were read with respect to intraventricular hemorrhage, ventriculomegaly, and echolucency, by multiple sonologists. Standardized neurological examinations classified cerebral palsy, and functional impairment was assessed. Forty-four percent with ventriculomegaly and 52% with echolucency developed cerebral palsy. Compared with no ultrasound abnormalities, children with echolucency were 24 times more likely to have quadriparesis and 29 times more likely to have hemiparesis. Children with ventriculomegaly were 17 times more likely to have quadriparesis or hemiparesis. Forty-three percent of children with cerebral palsy had normal head ultrasound. Focal white matter damage (echolucency) and diffuse damage (late ventriculomegaly) are associated with a high probability of cerebral palsy, especially quadriparesis. Nearly half the cerebral palsy identified at 2 years is not preceded by a neonatal brain ultrasound abnormality. |
| Databáze: | OpenAIRE |
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