Early Stages of Drug Discovery in an Academic Institution and Involvement of Pharma for Advancing Promising Leads
| Autor: | Frederick S. Buckner, Michael H. Gelb |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Drug Chagas disease medicine.medical_specialty Universities media_common.quotation_subject 030106 microbiology MEDLINE Article Academic institution 03 medical and health sciences Drug Discovery medicine Animals Humans Chagas Disease African trypanosomiasis Intensive care medicine media_common business.industry Drug discovery medicine.disease Malaria Clinical trial Trypanosomiasis African 030104 developmental biology Infectious Diseases business |
| Zdroj: | ACS Infect Dis |
| ISSN: | 2373-8227 |
| Popis: | In this Viewpoint we provide a brief description of two efforts to develop drugs to treat diseases caused by tropical parasites (Malaria, human African trypanosomiasis, and Chagas disease). These efforts are largely based in a University setting but draw heavily on Pharma for a complete progression from drug hit discovery to advancement toward clinical trials. The first case is the development of protein farnesyltransferase inhibitors, and the second case is a series of benzthiazoles, the target of which is being investigated. |
| Databáze: | OpenAIRE |
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