Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy
| Autor: | L H, Jensen, R, Altaf, H, Harling, M, Jensen, S, Laurberg, J C, Lindegaard, A, Muhic, L, Vestermark, A, Jakobsen, S, Bülow, Peer, Wille-Jørgensen |
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| Přispěvatelé: | Department of Oncology, Vejle Hospital, Herlev and Gentofte Hospital, Department of Surgery, Bispebjerg Hospital, Aarhus Hospital, Aarhus University Hospital, Rigshospitalet [Copenhagen], Copenhagen University Hospital-Copenhagen University Hospital, Odense Hospital, Hvidovre Hospital |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Colorectal cancer medicine.medical_treatment Denmark Population education Rectum 030230 surgery Preoperative care 03 medical and health sciences 0302 clinical medicine Preoperative Care medicine Humans Prospective Studies Prospective cohort study Survival rate ERROR Colectomy Aged Aged 80 and over education.field_of_study business.industry Rectal Neoplasms Incidence General Medicine Middle Aged medicine.disease 3. Good health Surgery Radiation therapy Survival Rate medicine.anatomical_structure Treatment Outcome Oncology 030220 oncology & carcinogenesis PURE Medicine Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | EJSO-European Journal of Surgical Oncology EJSO-European Journal of Surgical Oncology, WB Saunders, 2010, 36 (3), pp.237. ⟨10.1016/j.ejso.2009.10.008⟩ on behalf of the Danish Colorectal Cancer Group & Gandrup, P 2010, ' Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy ', European Journal of Surgical Oncology, vol. 36, no. 3, pp. 237-243 . https://doi.org/10.1016/j.ejso.2009.10.008 Jensen, L H, Altaf, R, Harling, H, Jensen, M, Laurberg, S, Lindegaard, J C, Muhic, A, Vestermark, L, Jakobsen, A & Bülow, S 2010, ' Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy ', European Journal of Surgical Oncology, vol. 36, no. 3, pp. 237-43 . https://doi.org/10.1016/j.ejso.2009.10.008 |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2009.10.008⟩ |
| Popis: | Udgivelsesdato: 2010-Mar AIM: The purpose of this study was to analyse the results of preoperative short course radiotherapy in a consecutive, national cohort of patients with rectal cancer. METHODS: Through a validated, prospective national database we identified 520 Danish patients who presented with high-risk mobile tumours in the lower two thirds of the rectum and were referred for preoperative radiotherapy with 5 x 5 Gy. The inclusion period was 56 months. Radiotherapy data was retrospectively collected. RESULTS: Of the 520 patients, 514 completed radiotherapy and 506 had surgery. Surgery was considered curative in 439 patients. The 3-year local recurrence rate was 4.0% (95% CI 2.5-6.5%) and the distant recurrence rate at 3 years was 18.7% (95% CI 15.4-22.5%). The 5-year disease free survival rate was 40.2% (95% CI 27.0-53.1%) and overall survival 50.4% (95% CI 36.1-63.1%). Most tumours (61%) were classified as T3 or T4 and 41% of the local recurrences occurred in patients with a fixed tumour at surgery. CONCLUSION: This study confirms data from randomised studies that the short course 5 x 5 Gy regime is a feasible treatment for locally advanced rectal cancer even when applied in a population outside clinical trials. |
| Databáze: | OpenAIRE |
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