Increased Chymase Activity in Internal Thoracic Artery of Patients With Hypercholesterolemia
| Autor: | Tadashi Tashiro, Noriyuki Sakata, Michio Kimura, Yoshinari Uehara, Hidenori Urata, Munehito Ideishi, Manabu Sasaguri, Kikuo Arakawa |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Arteriosclerosis Hypercholesterolemia Peptidyl-Dipeptidase A Cathepsin G Renin-Angiotensin System chemistry.chemical_compound Chymases Thoracic Arteries Internal medicine medicine.artery Adventitia Renin–angiotensin system Internal Medicine medicine Humans Aged Aorta biology business.industry Cholesterol Angiotensin II Serine Endopeptidases Chymase Angiotensin-converting enzyme Cholesterol LDL Middle Aged Immunohistochemistry medicine.anatomical_structure Endocrinology chemistry biology.protein Female business |
| Zdroj: | Hypertension. 35:55-60 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.35.1.55 |
| Popis: | Abstract —Apart from ACE, various angiotensin II (Ang II)–forming serine proteinases (eg, chymase, kallikrein, and cathepsin G) are known to exist in human tissues, but their clinical significance or the regulatory mechanisms that control their activities are not well established. A recent clinical study has shown that chymase activity was significantly increased in human atherosclerotic or aneurysmal aorta. The association between vascular Ang II–forming activities (AIIFAs) in the human internal thoracic artery (ITA) and various clinical parameters was studied with the use of ITAs obtained from 32 patients who underwent coronary artery bypass graft surgery. Total and ACE- and chymase-dependent AIIFAs in homogenates of ITAs were determined. Total AIIFA was 8.67±0.86 (nmol Ang II formed · min −1 · mg protein −1 [U]), and ≈95% of the activities were due to chymase. Serum total cholesterol level, but no other risk factors, significantly correlated with chymase- ( r =0.60, P r =0.35, P r =0.47, P |
| Databáze: | OpenAIRE |
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