Rheumatic manifestations of Chikungunya virus infection: Prevalence, patterns, and enthesitis
Autor: | Chintana Chirathaworn, Yong Poovorawan, Saovanee Benjamanukul, Manathip Osiri, Jira Chansaenroj |
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Rok vydání: | 2021 |
Předmět: |
Male
RNA viruses Viral Diseases NSAIDs Arthritis Pathology and Laboratory Medicine medicine.disease_cause Medical Conditions 0302 clinical medicine Skeletal Joints Odds Ratio Prevalence Medicine and Health Sciences Prospective Studies Chikungunya Musculoskeletal System Aged 80 and over Analgesics Chikungunya Virus Multidisciplinary Drugs virus diseases Chloroquine Middle Aged Infectious Diseases Medical Microbiology Viral Pathogens Viruses Medicine RNA Viral Female Polyarthritis Anatomy Pathogens medicine.symptom Research Article Neglected Tropical Diseases Adult medicine.medical_specialty Science Alphaviruses 030231 tropical medicine Pain Microbiology Togaviruses Young Adult Antimalarials 03 medical and health sciences Signs and Symptoms Rheumatology Tendinitis Rheumatic Diseases Internal medicine medicine Humans Spondylitis Ankylosing Microbial Pathogens Skeleton Rheumatic Pain Aged Neuropathic Pain Pharmacology 030203 arthritis & rheumatology Ankylosing spondylitis Tenosynovitis business.industry Organisms Enthesitis Chikungunya Infection Biology and Life Sciences Tropical Diseases medicine.disease Enthesis Pain management Logistic Models Chikungunya Fever Neuralgia Clinical Medicine business |
Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 4, p e0249867 (2021) |
ISSN: | 1932-6203 |
Popis: | Chikungunya virus (CHIKV) is an arthropod-borne virus transmitted by mosquitoes of the genus Aedes. CHIKV infection causes various rheumatic symptoms, including enthesitis; however, these effects are rarely investigated. The aim of this study was to describe the rheumatic manifestations in CHIKV infection, estimate the prevalence of enthesitis in CHIKV-infected patients, and determine the factors associated with CHIKV-induced enthesitis. We conducted a prospective, observational study in patients with CHIKV infection confirmed by positive RT-PCR or IgM assay from October 2019 to March 2020. Patients with pre-existing inflammatory rheumatic diseases were excluded. A rheumatologist evaluated the demographic and clinical characteristics of the patients, including the number of inflamed joints, enthesitis sites, tendinitis, and tenosynovitis. The Leeds enthesitis index (LEI) and the Maastricht ankylosing spondylitis enthesis score (MASES) were used to evaluate enthesitis sites. Factors associated with enthesitis were determined using logistic regression analysis. One hundred and sixty-four participants diagnosed with CHIKV infection were enrolled. The mean (SD) age of the patients was 48.2 (14) years. The most common pattern of rheumatic manifestations was polyarthritis with or without enthesitis. Enthesitis was observed in 63 patients (38.4%). The most common site of enthesitis was the left lateral epicondyle as assessed by LEI and the posterior superior iliac spine as assessed by MASES. Multivariate analysis indicated that the number of actively inflamed joints and Thai-HAQ score at the initial evaluation were significantly associated with the presence of enthesitis. The main rheumatic manifestations of CHIKV infection were arthritis/arthralgia, with enthesitis as a prominent extraarticular feature. CHIKV infection can cause enthesitis at peripheral and axial sites. We found that enthesitis was associated with a high number of inflamed joints and reduced physical function. These results indicate that the assessment of enthesitis should be considered when monitoring disease activity and as a treatment response parameter in CHIKV-infected patients. |
Databáze: | OpenAIRE |
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