Transformation of Small B-Cell Lymphoma Into Large Cell CD30+, CD4+, Epstein-Barr Virus–Negative Lymphoma
| Autor: | Roland Schwarting, Ly Ma, Kristina J. Fasig, Cindy L. Vnencak-Jones, Aaron C. Shaver, Annette S. Kim |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty CD30 Biopsy Gene Rearrangement B-Lymphocyte Heavy Chain Ki-1 Antigen Biology medicine.disease_cause Pathology and Forensic Medicine Diagnosis Differential immune system diseases hemic and lymphatic diseases medicine Humans Gene Rearrangement B-Lymphocyte B-cell lymphoma Lymphoma Follicular Histiocyte Large cell General Medicine Gene rearrangement Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Epstein–Barr virus Neoplasm Proteins Lymphoma Medical Laboratory Technology Cell Transformation Neoplastic Proto-Oncogene Proteins c-bcl-2 CD4 Antigens Lymphoma Large-Cell Anaplastic Immunoglobulin heavy chain Female Lymphoma Large B-Cell Diffuse Neoplasm Grading Biomarkers |
| Zdroj: | Archives of Pathology & Laboratory Medicine. 138:1101-1105 |
| ISSN: | 1543-2165 0003-9985 |
| Popis: | We report here 2 separate cases in which patients with known low-grade B-cell lymphomas presented with transformed lesions that were CD30+, CD4+, Epstein-Barr virus negative, and negative or focally weak for a wide range of B-cell, T-cell, and histiocytic/dendritic cell markers. In each case the transformed lymphoma possessed an identical pattern of immunoglobulin heavy chain and/or BCL2 rearrangement to the corresponding original low-grade B-cell lymphoma, confirming their identity as transformed B-cell lymphoma. A review of the relevant literature reveals that, to our knowledge, no transformed B-cell lymphomas with this immunophenotype have been previously reported, which creates the opportunity for potential errors of diagnosis. These cases highlight the importance of correlation with the patient's history and with molecular genetic results in rendering an accurate diagnosis. |
| Databáze: | OpenAIRE |
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