Biology of interleukin-38 and its role in chronic inflammatory diseases
| Autor: | Huasong Xia, Yanqing Wu, Meng Li, Yang Fu, Yue Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Inflammation
0301 basic medicine Pharmacology Autoimmune disease Signal peptide Cell type Interleukins medicine.medical_treatment Immunology Interleukin Biology medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cytokine 030220 oncology & carcinogenesis Chronic Disease medicine Animals Humans Immunology and Allergy Maturation process Receptor |
| Zdroj: | International Immunopharmacology. 95:107528 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2021.107528 |
| Popis: | Interleukin (IL)-38 is the tenth member of the IL-1 cytokine family. IL-38 shares high similarity with IL-36Ra and IL-1Ra and can bind to their receptors, thus exerting an anti-inflammatory effect. Despite the lack of a signal peptide, IL-38 can be released from several cell types, but its maturation process remains obscure. The role of IL-38 in numerous inflammatory diseases, especially in autoimmune diseases, has been extensively studied. In this review, we discuss the characteristics, biological functions and pathways of IL-38, as well as its role in several chronic inflammatory diseases. Better understanding the role of IL-38 will pave the way for clinical treatments in the near future. |
| Databáze: | OpenAIRE |
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