High-performance liquid chromatographic determination of ambroxol in human plasma
| Autor: | Jiří Pastera, Dalibor Svoboda, Milan Nobilis, Jaroslav Květina, Karel Macek |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Chromatography Chemistry Silica gel Extraction (chemistry) Ambroxol General Chemistry High-performance liquid chromatography chemistry.chemical_compound Bromhexine Oral administration Human plasma Reference Values Healthy volunteers medicine Humans Female Spectrophotometry Ultraviolet Quantitative analysis (chemistry) Biotransformation Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | Journal of chromatography. 581(2) |
| Popis: | Ambroxol has been determined in biological fluids using a rapid and sensitive high-performance liquid chromatographic method. The samples prepared from plasma by liquid—liquid extraction were analysed on reversed-phase silica gel by competing-ion chromatography with ultraviolet detection. The method was applied to the determination of ambroxol levels in twelve healthy volunteers after oral administration of 90 mg of ambroxol in tablets of Mucosolvan and Ambrosan. |
| Databáze: | OpenAIRE |
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