Plasma omega 3 polyunsaturated fatty acid status and monounsaturated fatty acids are altered by chronic social stress and predict endocrine responses to acute stress in titi monkeys
| Autor: | Karen L. Bales, J. B. German, Sally P. Mendoza, J.T. Smilowitz, Michael R. Jarcho, Kevin D. Laugero |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Hydrocortisone Clinical Biochemistry Biology Fatty Acids Monounsaturated chemistry.chemical_compound Internal medicine Fatty Acids Omega-3 medicine Animals Insulin Chronic stress Social Behavior Triglycerides Unsaturated fatty acid chemistry.chemical_classification Social stress Adiponectin Fatty acid metabolism Cholesterol Phosphatidylethanolamines Fatty acid Haplorhini Cell Biology Endocrinology chemistry Stearoyl-CoA Desaturase Stress Psychological Polyunsaturated fatty acid |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 84:71-78 |
| ISSN: | 0952-3278 |
| DOI: | 10.1016/j.plefa.2010.12.003 |
| Popis: | Disturbances in fatty acid (FA) metabolism may link chronic psychological stress, endocrine responsiveness, and psychopathology. Therefore, lipid metabolome-wide responses and their relationships with endocrine (cortisol, insulin, and adiponectin) responsiveness to acute stress (AS) were assessed in a primate model of chronic social stress (CS). Compared to controls (not exposed to CS), CS increased (P≤0.05) circulating triacylglycerol (TG) and phosphatidylethanolamine (PE) n-6/n-3 and reduced (P≤0.05) cholesterol ester (CE) 16:1n7 and phosphatidylcholine (PC) 18:1n7, suggesting lower omega-3 FA status and stearoyl-CoA desaturase activity, respectively. Cortisol responses to AS positively correlated with TG n-6/n-3 (r=0.93; P=0.007), but only in CS monkeys. The adiponectin response to AS inversely correlated with CE n-6/n3 (r=-0.89; P=0.045) and positively with TG 16:1n7 (r=0.98; P=0.004), only in CS monkeys. Our results are consistent with previously reported FA profiles in stress-related psychopathology and suggest that compositional changes of specific lipid FAs may form new functional markers of chronic psychological stress. |
| Databáze: | OpenAIRE |
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