Association of Aryl Hydrocarbon Receptor-Related Gene Variants with the Severity of Autism Spectrum Disorders
| Autor: | Nobumasa Kato, Kazuyuki Shinohara, Junko Matsuzaki, Ryoichiro Iwanaga, Shota Nishitani, Chisato Kawasaki, Mamoru Tochigi, Tsukasa Sasaki, Takashi X. Fujisawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aryl hydrocarbon receptor nuclear translocator lcsh:RC435-571 Biology Polymorphism Single Nucleotide Severity 03 medical and health sciences 0302 clinical medicine lcsh:Psychiatry Genotype medicine Autism spectrum disorder Polymorphism Pathological Gene Aryl hydrocarbon receptor Original Research Psychiatry Genetics Sexual differentiation Social communication medicine.disease Autism Spectrum Disorders Psychiatry and Mental health 030104 developmental biology biology.protein Autism 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Psychiatry, Vol 7 (2016) Frontiers in Psychiatry |
| ISSN: | 1664-0640 |
| Popis: | Exposure to environmental chemicals, such as dioxin, is known to have adverse effects on the homeostasis of gonadal steroids, thereby potentially altering the sexual differentiation of the brain to express autistic traits. Dioxin-like chemicals act on the aryl hydrocarbon receptor (AhR), polymorphisms, and mutations of AhR-related gene may exert pathological influences on sexual differentiation of the brain, causing autistic traits. To ascertain the relationship between AhR-related gene polymorphisms and autism susceptibility, we identified genotypes of them in patients and controls and determined whether there are different gene and genotype distributions between both groups. In addition, to clarify the relationships between the polymorphisms and the severity of autism, we compared the two genotypes of AhR-related genes (rs2066853, rs2228099) with the severity of autistic symptoms. Although no statistically significant difference was found between autism spectrum disorder (ASD) patients and control individuals for the genotypic distribution of any of the polymorphisms studied herein, a significant difference in the total score of severity was observed in rs2228099 polymorphism, suggesting that the polymorphism modifies the severity of ASD symptoms but not ASD susceptibility. Moreover, we found that a significant difference in the social communication score of severity was observed. These results suggest that the rs2228099 polymorphism is possibly associated with the severity of social communication impairment among the diverse ASD symptoms. Frontiers in Psychiatry, 7, 184; 2016 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|