Frequency of anaplastic lymphoma kinase rearrangements in Moroccan patients with non small cell lung cancer: a multi-institutional national retrospective study

Autor: Ibrahim Elghissassi, Hassan Errihani, Hind El Yacoubi, Mohamed Lemine Sow, Amina Mestari, Lamia Gamra, Lamia Jabri, Fouad Kettani
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Oncology
Cancer Research
Lung Neoplasms
0302 clinical medicine
Surgical oncology
Carcinoma
Non-Small-Cell Lung
hemic and lymphatic diseases
Anaplastic lymphoma kinase
Anaplastic Lymphoma Kinase
030212 general & internal medicine
Prospective cohort study
In Situ Hybridization
Fluorescence
Aged
80 and over
Gene Rearrangement
education.field_of_study
medicine.diagnostic_test
Age Factors
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Immunohistochemistry
Morocco
030220 oncology & carcinogenesis
Adenocarcinoma
Female
Research Article
Adult
medicine.medical_specialty
Population
Morroco
lcsh:RC254-282
03 medical and health sciences
Sex Factors
Internal medicine
Biopsy
Genetics
medicine
Humans
education
Lung cancer
Aged
Retrospective Studies
business.industry
Retrospective cohort study
Anaplastic lymphoma kinase rearrangement
Frequency
medicine.disease
Non small cell lung cancer
business
Zdroj: BMC Cancer, Vol 20, Iss 1, Pp 1-5 (2020)
BMC Cancer
ISSN: 1471-2407
Popis: Background Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ALK inhibitors in non small cell lung cancer (NSCLC). The prevalence of ALK rearrangements is well known in Whites and Asians. However, data identifying the frequency of this rearrangement in Moroccan and North African population are lacking. The objective of this study is to report the frequency of ALK rearrangement in a group of Moroccan patients with NSCLC. Methods A retrospective study was performed enrolling 120 Moroccan patients with NSCLC whose biopsy samples were tested for ALK rearrangement in order to identify the frequency of ALK rearrangement and its potential association with selected variables. The ALK testing was established using fluorescent in situ hybridization (FISH) or immunohistochemistry (IHC). Results The frequency of ALK rearrangement was 4.2% (5/120). All positive cases were males with advanced adenocarcinoma. ALK rearrangements prevalence was significantly higher in older patients. Conclusions The frequency of ALK rearrangements among the Moroccan population tends to correlate with the average frequency reported worldwide, with some specific features. Further prospective studies with larger patients’ numbers are needed to verify these findings.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje