Comparing the Effects of Two Different Levels of Hyperoxygenation on Gas Exchange During Open Endotracheal Suctioning: A Randomized Crossover Study

Autor: Jacqueline Rodrigues de Freitas Vianna, Mauricio Jamami, Valéria Amorim Pires Di Lorenzo, Miléa Mara Lourenço da Silva Simões
Rok vydání: 2016
Předmět:
Male
medicine.medical_treatment
Critical Care and Intensive Care Medicine
Hypoxemia
0302 clinical medicine
Heart Rate
Single-Blind Method
Oximetry
Prospective Studies
Hypoxia
Tidal volume
Aged
80 and over
Capnography
Cross-Over Studies
medicine.diagnostic_test
General Medicine
Middle Aged
respiratory system
Trachea
Anesthesia
Female
medicine.symptom
circulatory and respiratory physiology
Pulmonary and Respiratory Medicine
Mean arterial pressure
Respiratory rate
Suction
03 medical and health sciences
Respiratory Rate
Intubation
Intratracheal
Tidal Volume
medicine
Humans
Arterial Pressure
Aged
Mechanical ventilation
Pulmonary Gas Exchange
business.industry
030208 emergency & critical care medicine
Respiratory Dead Space
Carbon Dioxide
Respiration
Artificial
respiratory tract diseases
Oxygen
Pulse oximetry
030228 respiratory system
Pulmonary Ventilation
business
Respiratory minute volume
Zdroj: Respiratory Care. 62:92-101
ISSN: 1943-3654
0020-1324
Popis: BACKGROUND: Endotracheal suctioning is required for mechanically ventilated patients to maintain a patent airway. Studies show that open endotracheal suctioning affects respiratory mechanics and gas exchange. The aim of this study was to compare the effectiveness of hyperoxygenation with FIO2 + 0.20 above baseline and hyperoxygenation with FIO2 1.0 in preventing hypoxemia, and to determine the impact of open endotracheal suctioning on the pulmonary ventilation of critical subjects receiving mechanical ventilatory support. METHODS: This prospective randomized crossover study was conducted in the ICU. Sixty-eight mechanically ventilated subjects with FIO2 ≤ 0.6 and requiring endotracheal suctioning were included in this study. Open endotracheal suctioning was performed using 2 different intervention sequences: hyperoxygenation of 0.20 above baseline FIO2 (FIO2 + 0.20) and 1.0 hyperoxygenation (FIO2 1.0). Oxygenation was assessed via oxygen saturation as measured by pulse oximetry (SpO2), and changes in lung ventilation were measured via alveolar gas volume (VA), alveolar minute volume (VA min), carbon dioxide (CO2) production (VCO2), mixed exhaled partial pressure of CO2 (PECO2), exhaled tidal CO2 volume (VTCO2), end-tidal CO2 (PETCO2), anatomical dead space to tidal volume ratio (VD/VT), and anatomical dead space volume of each breath (VD) using volumetric capnography, and breathing frequency (f), heart rate, and mean arterial pressure using a multiparameter monitor. RESULTS: SpO2 levels were significantly higher within interventions (FIO2 + 0.20 and 1.0) 1 min before and after suction. Also, there was a significant increase in PETCO2, PECO2, heart rate, and mean arterial pressure immediately after the procedure compared with baseline, and in VTCO2, only for FIO2 + 0.20. Baseline values were not found to be significantly different between the groups in case of any dependent variable. CONCLUSIONS: In mechanically ventilated adult subjects, hyperoxygenation with FIO2 + 0.20 above baseline prevents hypoxemia. Also, transient changes in pulmonary ventilation with open circuit suctioning were confirmed by volumetric capnography analysis. (Trial registration: ClinicalTrials.gov NCT02440919).
Databáze: OpenAIRE
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