Metabolic sequelae of respiratory Q fever in the guinea pig
Autor: | S. V. Machotka, Michael C. Powanda, R. A. Kishimoto |
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Rok vydání: | 1978 |
Předmět: |
Male
Time Factors Q fever Spleen Biology General Biochemistry Genetics and Molecular Biology Body Temperature Guinea pig Mice Blood plasma medicine Animals Respiratory system Lung Respiratory Tract Infections Macrophages Organ Size Orosomucoid medicine.disease Coxiella burnetii biology.organism_classification Pneumonia Disease Models Animal Zinc medicine.anatomical_structure Immunology Muramidase Q Fever Copper |
Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 158(4) |
ISSN: | 0037-9727 |
Popis: | SummaryGuinea pigs infected with Coxiella burnetii administered in small particle aerosols provides a model for naturally acquired respiratory Q fever. Increases in plasma copper and seromucoid concentrations and in lysozyme activity along with a decrease in plasma zinc paralleled increases in body temperature, spleen and lung weights, and the development of lesions. Circumstantial evidence indicates that these metabolic alterations may be related to the interaction between pulmonary macrophages and the parasite. These metabolic sequelae thus may have prognostic value in that they appear related to the disease process and are less likely to be obscured than fever or rickettsemia. |
Databáze: | OpenAIRE |
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