Clinical profiles of hyperglycemic crises: A single‐center retrospective study from Japan

Autor: Eiichi Araki, Shoko Kodama-Hashimoto, Yuma Ohkubo, Tomoaki Yoshinaga, Hiroyuki Kinoshita, Takeshi Takahashi, Takeshi Nishikawa, Keiko Ono, Tetsushi Toyonaga, Yuka Kobayashi, Tomofumi Nakamura, Masahiro Harada
Rok vydání: 2021
Předmět:
Adult
Blood Glucose
Male
medicine.medical_specialty
Diabetic ketoacidosis
Endocrinology
Diabetes and Metabolism
Acute arterial occlusion
Arterial Occlusive Diseases
030209 endocrinology & metabolism
Single Center
Diseases of the endocrine glands. Clinical endocrinology
Diabetic Ketoacidosis
Fibrin Fibrinogen Degradation Products
03 medical and health sciences
0302 clinical medicine
Japan
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Aged
Retrospective Studies
Aged
80 and over
Fibrin degradation product
business.industry
Mortality rate
Retrospective cohort study
Articles
General Medicine
Blood Coagulation Disorders
Middle Aged
RC648-665
Hyperglycemic hyperosmotic syndrome
medicine.disease
Diabetes Mellitus
Type 1
Clinical Science and Care
Hyperglycemia
Coagulation disorders
Consciousness Disorders
Hyperglycemic Hyperosmolar Nonketotic Coma
Female
Original Article
business
030217 neurology & neurosurgery
Zdroj: Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 12, Iss 8, Pp 1359-1366 (2021)
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.13475
Popis: Aims/Introduction The aim of the present study was to clarify the pathophysiologies of hyperglycemic crises in Japanese patients. Materials and Methods This was a retrospective study of patients with hyperglycemic crises admitted to Kumamoto Medical Center, Kumamoto, Japan, between 2012 and 2019. Patients were classified as having diabetic ketoacidosis (DKA), hyperglycemic hyperosmotic syndrome (HHS) or a mixed state of the two conditions (MIX), and laboratory data and levels of consciousness at hospital admission, as well as the rates of mortality and coagulation disorders, were compared. Results The diagnostic criteria for hyperglycemic crisis were met in 144 cases, comprising 87 (60.4%), 38 (26.4%) and 19 (13.2%) cases of DKA, HHS and MIX, respectively. Type 1 diabetes was noted in 46.0 and 26.3% of patients in the DKA and MIX groups, respectively. Fibrin degradation product and D‐dimer levels were significantly higher in the HHS group than in the DKA group (DKA and HHS groups: fibrin degradation product 7.94 ± 8.43 and 35.54 ± 51.80 μg/mL, respectively, P
We carried out a retrospective analysis of patients with hyperglycemic crises who were treated in our hospital between 2012 and 2019 (n = 144), because the pathologies of hyperglycemic crisis appear to be influenced by racial differences. The frequency of type 1 diabetes in Japanese patients with diabetic ketoacidosis and a mixed state of diabetic ketoacidosis and hyperglycemic hyperosmotic syndrome was lower than in white people. Patients with hyperglycemic hyperosmotic syndrome and a mixed state of diabetic ketoacidosis and hyperglycemic hyperosmotic syndrome showed increased coagulability, and patients with a mixed state of diabetic ketoacidosis and hyperglycemic hyperosmotic syndrome had a significantly higher incidence of acute arterial occlusive disease than patients with diabetic ketoacidosis and hyperglycemic hyperosmotic syndrome.
Databáze: OpenAIRE
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