Mycobacterium abscessus pulmonary infection during hepatitis C treatment with telaprevir, peginterferon and ribavirin
| Autor: | Francisco Barrera, M. Elvira Balcells, Jaime Labarca, Carlos Benítez, Pilar Labbé, Marco Arrese, Arnoldo Riquelme, Alejandro Soza, Alvaro Huete |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Imipenem medicine.medical_specialty Mycobacterium Infections Nontuberculous Specialties of internal medicine Mycobacterium abscessus Antiviral Agents Gastroenterology Mycobacterium Polyethylene Glycols Telaprevir Immunocompromised Host chemistry.chemical_compound Boceprevir Internal medicine Lymphopenia Ribavirin Pneumonia Bacterial medicine Humans Peginterferon Aged Hepatology biology business.industry Interferon-alpha virus diseases General Medicine Hepatitis C Hepatitis C Chronic biology.organism_classification medicine.disease Recombinant Proteins chemistry RC581-951 Amikacin Immunology HCV Drug Therapy Combination Complication business Oligopeptides medicine.drug |
| Zdroj: | Annals of Hepatology, Vol 14, Iss 1, Pp 132-136 (2015) |
| ISSN: | 1665-2681 |
| Popis: | The first generation protease inhibitors has been the mainstay of hepatitis C treatment for the last couple of years, showing marked improvement in sustained virological response, but also increased side effects. Infection has emerged as a common complication of telaprevir and boceprevir in combination with peginterferon and ribavirin, usually caused by common pathogens. We present the case of a 65 years old man who developed a Mycobacterium abscessus pulmonary infection during treatment with telaprevir, peginterferon and ribavirin. The patient was successfully treated with amikacin, imipenem and chlarithro-mycin. The present case is relevant for increasing awareness for recognition of opportunistic infections and particularly nontuberculous mycobacterial infections in patients receiving triple therapy for chronic hepatitis C, especially in cirrhotic subjects who develop significant lymphopenia. |
| Databáze: | OpenAIRE |
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