Evaluation of carotis intima media thickness in chronic obstructive pulmonary disease patients
| Autor: | Ömer Yazgan, Elif Önder, Talha Dumlu, Fahri Halit Besir, Melih Engin Erkan, Leyla Yilmaz Aydin, Hulya Coskun |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Adolescent Comorbidity Critical Care and Intensive Care Medicine Logistic regression Systemic inflammation Carotid Intima-Media Thickness Pulmonary function testing Pulmonary Disease Chronic Obstructive Young Adult Risk Factors Internal medicine Humans Medicine Young adult Aged Aged 80 and over COPD business.industry Case-control study Middle Aged Atherosclerosis medicine.disease Respiratory Function Tests Intima-media thickness Case-Control Studies Cardiology Female Surgery medicine.symptom Tunica Intima Tunica Media business |
| Zdroj: | Tuberkuloz ve Toraks. :238-245 |
| ISSN: | 0494-1373 |
| DOI: | 10.5578/tt.3779 |
| Popis: | INTRODUCTION Chronic obstructive pulmonary disease (COPD) and atherosclerosis may occur due to similar risk factors and have a significant cause of morbidity and mortality. In this study to assess the relationship between COPD and atherosclerosis; carotid intima media thickness (CIMT) of COPD patients and adult healthy individuals with normal body mass index and metabolic parameters compared. MATERIALS AND METHODS 2298 participants aged between 18-92; 46 patients diagnosed with COPD according to clinical features and pulmonary function tests the study, 47 healthy controls who do not have exclusion criteria were evaluated. Doppler ultrasound was performed for the assessment of CIMT to all participants. p values < 0.05 were considered to be significant. RESULTS Mean CIMT in COPD group and control group were 0.79 ± 0.16 mm and 0.616 ± 0.1 mm, respectively (p< 0.001). In multiple linear regression analysis that made to determine the atherosclerotic risk parameters affecting CIMT; it was found that CIMT was related to age with direct proportion (p= 0.002) and to FEV(1)% with inversely proportion (p= 0.04). In multivariate logistic regression analysis that made to determine the parameters affecting atherosclerosis; we found that any parameters were related with atherosclerosis. CONCLUSION Persistent low-grade systemic inflammation in COPD and atherosclerotic disease may possibly have been reported a factor in both pathologies. Early atherosclerosis and cardiovascular risks in adults with COPD increase independent of risk factors. CIMT which shows direct proportion with age and inverse proportion with FEV(1)% is a non-invasive, easily applicable and cheap method that can be used in determining the risk of atherosclerosis. |
| Databáze: | OpenAIRE |
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