RAPID DEVELOPMENT OF IATROGENIC CUSHING SYNDROME IN A PATIENT ON RITONAVIR: THE ADVERSE METABOLIC CONSEQUENCE OF TOPICAL STEROID USE
| Autor: | L. Maria Belalcazar, Ruba Riachy, Jeremy D. Purser, Lucas S. Blanton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment MEDLINE 030209 endocrinology & metabolism General Medicine Case Reports medicine.disease RC648-665 Dermatology Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences Cushing syndrome Iatrogenic Cushing Syndrome 0302 clinical medicine 030220 oncology & carcinogenesis Medicine Ritonavir business medicine.drug Topical steroid |
| Zdroj: | AACE Clin Case Rep AACE Clinical Case Reports, Vol 6, Iss 6, Pp e346-e348 (2020) |
| Popis: | Objective: Topical steroid use is common, but its association with Cushing syndrome is rare. We report the rapid development of iatrogenic Cushing syndrome in a patient on ritonavir who applied a moderate-potency topical steroid cream, triamcinolone, on his genital mucosa for treatment of phimosis. Methods: Clinical and diagnostic challenges associated with topical steroid use are presented and discussed. Results: A 41-year-old man with human immunodeficiency virus infection on stable antiretroviral therapy that included ritonavir, a cytochrome P450 3A4 inhibitor, presented with new onset diabetes and development of overt cushingoid features over a 4-week period. He reported no known history of steroid use. A midnight salivary cortisol using a quantitative enzyme immunoassay was obtained and reported at >15.0 μg/dL (normal |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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