Genomics and proteomics of retinopathy of prematurity: DNA‐based prevention and treatment
| Autor: | W V Good, R L Gendron |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Vascular Endothelial Growth Factor A
Pathology medicine.medical_specialty Genomics Nerve Tissue Proteins Bioinformatics Proteomics Cellular and Molecular Neuroscience Sex Factors Retinal Diseases medicine Animals Humans Genetic Predisposition to Disease Retinopathy of Prematurity Insulin-Like Growth Factor I Eye Proteins Polymorphism Genetic Eye Color business.industry Infant Newborn Retinopathy of prematurity medicine.disease Sensory Systems Oxygen Ophthalmology Disease Models Animal Editorial Mutation business |
| Popis: | Despite advances in management and treatment, retinopathy of prematurity remains a major cause of childhood blindness. Evidence for a genetic basis for susceptibility to retinopathy of prematurity is examined, including the influences of sex, ethnicity, and ocular pigmentation. The role of polymorphisms is explored in the genes for vascular endothelial growth factor and insulin-like growth factor-1, and of mutations in the Norrie disease gene. Insights into the genetic basis of retinopathy of prematurity provided by the animal model of oxygen induced retinopathy are examined. Evidence for a genetic component for susceptibility to retinopathy of prematurity is strong, although the molecular identity of the gene or genes involved remains uncertain. |
| Databáze: | OpenAIRE |
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